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Microparticles and microscopic structures in three fractions of fresh cerebrospinal fluid in schizophrenia: Case report of twins

Mobarrez, F. (författare)
Nybom, R. (författare)
Johansson, V. (författare)
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Hultman, C. M. (författare)
Wallen, H. (författare)
Landén, Mikael, 1966- (författare)
Göteborgs universitet, Institutionen för neurovetenskap och fysiologi, Gothenburg University, Institute of Neuroscience and Physiology
Wetterberg, L. (författare)
Landen, M, (författare)
Karolinska Institutet
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Göteborgs universitet Sahlgrenska akademin. Institutionen för neurovetenskap och fysiologi. 
2013
Engelska.
Ingår i: Schizophrenia Research. - 0920-9964 .- 1573-2509. ; 143:1, s. 192-197
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Schizophrenia is a diagnosis with a set of symptoms of aberrant psychological phenomena. Here, we discuss that there may be an imbalance of proteostasis of neurons in the brain leading to increase in membrane shedding and buildup of microparticles (MPs) appearing in the cerebrospinal fluid. The number of MPs can be determined and their phenotypes verified by size and membrane expression with flow cytometry. This is the first report of specified MPs in cerebrospinal fluid (CSF) in schizophrenia. Two 56-year-old Swedish-born female monozygotic twins of Caucasian ethnicity with onset of schizophrenia more than 30 years ago were studied. Three fractions of fresh CSF were examined for microparticles by flow cytometry analysis, which measure the specific binding of antibodies to CD42a (platelet-MP; 33 GPIX), CD144 (endothelial-MP; Ve-cadherin), CD45 (leukocyte-MP; pan-leukocyte antigen) and of phosphatidylserine to lactadherin. The patients with schizophrenia displayed more phosphatidylserine-positive MPs in CSF compared with healthy control subjects. The scanning electron microscopic (SEM) structures in CSF studied over a 3-year period in twins with schizophrenia were of similar appearance at both time points. The increased number of MPs in fresh CSF may be a sign of enhanced membrane shedding in the central nervous system. Such MPs can be investigated for both human and non-human DNA, RNA and microRNA that may activate different immune signaling systems in patients with schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

Cerebrospinal fluid
Flow cytometry
Microparticles Scanning electron microscopy
Schizophrenia
neurological disorders
membrane-particles
apoptotic cells
csf
products
receptor
virus
NETICSnullAtkin
Talia A.Atkin
TABrandon
Nicholas J.Brandon
NJKittler
Josef T.Kittler
Deane
RashidDeane
RGoldman
Steven A.Goldman
SANagelhus
Erlend A.Nagelhus
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