An international multicentre study on the allergenic activity of air-oxidized R-limonene

Bråred Christensson, Johanna,1965Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Institutionen för kemi och molekylärbiologi,Institute of Clinical Sciences, Department of Dermatology and Venereology,Department of Chemistry and Molecular Biology (författare)

restricted
Background. Limonene is a common fragrance terpene that, in its pure form, is not allergenic or is a very weak allergen. However, limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. Oxidized R-limonene has previously been patch tested in multicentre studies, giving 2–3% positive patch test reactions in consecutive patients. Objectives. To investigate whether oxidized R-limonene 3.0% in petrolatum, with a stable concentration of the main haptens, limonene hydroperoxides (Lim-OOHs), could be a useful tool for the detection of contact allergy in an international setting. Methods. Oxidized R-limonene 3.0% (Lim-OOHs 0.33%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United Kingdom, Singapore, Spain, Sweden, and Australia. Results. Overall, 5.2% (range 2.3–12.1%) of the patients showed a positive patch test reaction to oxidized R-limonene. Doubtful reactions were found in 7.0% of the patients (range 0–24%). Few irritant reactions were seen. Conclusions. Oxidized R-limonene at 3.0% pet. with a specified content of Lim-OOHs 0.33% is a standardized and useful tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized R-limonene would not be informed of their fragrance allergy if this specific test had not been performed.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
allergic contact dermatitis
autoxidation
CAS 5989-27-5
dose per unit area
fragrance allergy
potent contact allergens
dermatitis patients
skin sensitization
oxidation-products
fragrance terpenes
citrus solvent
linalool
hydroperoxide
autoxidation
exposure

Andersen, K. E. (författare)
Bruze, M. (författare)
Johansen, J. D. (författare)
Garcia-Bravo, B. (författare)
Gimenez-Arnau, A. (författare)
Goh, C. L. (författare)
Nixon, R. (författare)
White, I. R. (författare)
Giménez-Arnau, Ana (författare)
Bruze, MagnusLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups(Swepub:lu)derm-mbr (författare)
Garcia-Bravo, Begoña (författare)
Goh, Chee-Leok (författare)
Johansen, Jeanne D (författare)
Andersen, Klaus E (författare)
White, Ian R (författare)
Nixon, Rosemary (författare)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi (creator_code:org_t)
Göteborgs universitet
Gothenburg University
Göteborgs universitet
Gothenburg University

Ingår i:Contact Dermatitis: Federation of European Neuroscience Societies and Blackwell Publishing Ltd68:4, s. 214-2230105-1873

Av författaren/redakt...: Bråred Christens ...; Andersen, K. E.; Bruze, M.; Johansen, J. D.; Garcia-Bravo, B.; Gimenez-Arnau, A ...; visa fler...; Goh, C. L.; Nixon, R.; White, I. R.; Giménez-Arnau, A ...; Bruze, Magnus; Garcia-Bravo, Be ...; Goh, Chee-Leok; Johansen, Jeanne ...; Andersen, Klaus ...; White, Ian R; Nixon, Rosemary; visa färre...

Om ämnet