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Subjective health p...
Subjective health perception in healthy young men changes in response to experimentally restricted sleep and subsequent recovery sleep
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- Lekander, Mats (författare)
- Stockholms universitet,Stressforskningsinstitutet,Karolinska Institutet, Sweden
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- Andreasson, A. N. (författare)
- Stockholms universitet,Stressforskningsinstitutet,Karolinska Institutet, Sweden
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- Kecklund, Göran (författare)
- Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet
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- Ekman, Rolf, 1938 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Ingre, Michael (författare)
- Stockholms universitet,Stressforskningsinstitutet
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- Åkerstedt, Torbjorn (författare)
- Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet
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- Axelsson, J. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- Engelska.
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Ingår i: Brain Behavior and Immunity. - : Elsevier BV. - 0889-1591 .- 1090-2139. ; 34, s. 43-46
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Sleep and subjective health are both prospectively related to objective indices of health and health care use. Here, we tested whether five days with restricted sleep and subsequent recovery days affect subjective health and is related to increased levels of circulating IL-6 and TNF-alpha and fatigue. Nine healthy men (23-28 years) went through a 6-week sleep protocol with subjects as their own controls in a repeated measures design with a total of 11 nights in a sleep laboratory. The experimental part of the protocol included three baseline days (sleep 23-07 h), five days with sleep restriction (03-07 h) and three recovery days (23-07 h) in the sleep laboratory. Subjective health and fatigue was recorded daily. Eight blood samples were drawn each day (every third hour) on 8 days of the protocol and analyzed with respect to IL-6 and TNF-alpha. Subjective health deteriorated gradually during restricted sleep (p = .002) and returned to baseline levels after three days of recovery. IL-6 and TNF-alpha did not change significantly. Fatigue increased gradually during sleep restriction (p = .001), which significantly contributed to the association between restricted sleep and subjective health. The study is the first to show that subjective health is directly responsive to changes in sleep length and related to increased fatigue. Thus, subjective health is differently appraised after manipulation of one of its presumed determinants. Larger experimental studies would be beneficial to further distinguish causation from association regarding the underpinnings of subjective health. (C) 2013 Published by Elsevier Inc.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Subjective health
- Self-rated health
- Inflammation
- Sleep
- Sleep restriction
- Fatigue
- Cytokines
- SELF-RATED HEALTH
- INFLAMMATORY CYTOKINES
- INTERLEUKIN-6
- MARKERS
- WOMEN
- DEPRIVATION
- POPULATION
- MORTALITY
- DURATION
- INSOMNIA
- Subjective health
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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