SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:gup.ub.gu.se/242742"
 

Sökning: onr:"swepub:oai:gup.ub.gu.se/242742" > The engagement of o...

The engagement of oral-associated lymphoid tissues during oral versus gastric antigen administration

Bankvall, Maria, (författare)
Göteborgs universitet, Institutionen för odontologi, sektion 1, Gothenburg University, Institute of Odontology, Section 1
Ostberg, Anna Karin, (författare)
Göteborgs universitet, Institutionen för odontologi, sektion 3, Gothenburg University, Institute of Odontology, Section 3
Jontell, Mats, 1951- (författare)
Göteborgs universitet, Institutionen för odontologi, Gothenburg University, Institute of Odontology
visa fler...
Wold, Agnes E, 1955- (författare)
Göteborgs universitet, Institutionen för biomedicin, avdelningen för infektionssjukdomar, Gothenburg University, Institute of Biomedicine, Department of Infectious Medicine
Östman, Sofia M, 1974- (författare)
Göteborgs universitet, Institutionen för biomedicin, avdelningen för infektionssjukdomar, Gothenburg University, Institute of Biomedicine, Department of Infectious Medicine
visa färre...
Göteborgs universitet Sahlgrenska akademin. Institutionen för odontologi, sektion 1. 
Göteborgs universitet Sahlgrenska akademin. Institutionen för odontologi, sektion 3. 
visa fler...
Göteborgs universitet Sahlgrenska akademin. Institutionen för odontologi. 
Göteborgs universitet Sahlgrenska akademin. Institutionen för biomedicin, avdelningen för infektionssjukdomar. 
visa färre...
2016
Engelska.
Ingår i: Immunology. - 0019-2805. ; 149:1, s. 98-110
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The role of oral-associated lymphoid tissues during induction of oral tolerance still remains elusive. Therefore, the aim was to compare T-cell activation and induction of tolerance to ovalbumin (OVA) presented through either of two routes; deposited into the oral cavity, or the stomach, thereby bypassing the oral cavity. OVA was administered by the oral or gastric route to BALB/c mice that had received OVA-specific DO11.10+ CD4(+) T cells, stained with CellTrace Violet dye, through intravenous injection. Proliferating OVA-specific T cells were detected in the nose-associated lymphoid tissues (NALT) and the cervical, mesenteric and peripheral lymph nodes at different time-points following OVA exposure. OVA-specific T-cell proliferation was initially observed in the NALT 1hr after oral, but not gastric, administration. However, at day 1, proliferation at this site was also detected after gastric administration and profound proliferation was observed at all sites by day 4. For the oral route the degree of proliferation observed was lower in the peripheral lymph nodes by day 4 compared with the other sites. These results demonstrate a similar activation pattern achieved by the two routes. However, the NALT distinguishes itself as a site of rapid T-cell activation towards fed antigens irrespective of feeding regimen. To evaluate induction of tolerance a semi-effective OVA dose was used, to detect differences in the degree of tolerance achieved. This was performed in a model of OVA-induced airway hypersensitivity. No differences in tolerance induction were observed between the two administration routes.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

antigen administration
cervical lymph nodes
murine model
nose-associated lymphoid tissues
intestinal immune-system
t-cells
mucosal tolerance
sublingual
immunotherapy
immunological-tolerance
mice
suppression
induction
mechanisms
nodes
Immunology

Publikations- och innehållstyp

art (ämneskategori)
ref (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Sök utanför SwePub

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy