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Tumour recurrence and enlargement in patients with craniopharyngioma with and without GH replacement therapy during more than 10 years of follow-up.

Olsson, Daniel S, 1983 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Buchfelder, M (författare)
Wiendieck, K (författare)
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Kremenevskaja, N (författare)
Bengtsson, Bengt-Åke, 1944 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Jakobsson, Karl-Erik, 1948 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Jarfelt, Marianne, 1962 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences,Institute of Clinical Sciences, Department of Pediatrics
Johannsson, Gudmundur, 1960 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Nilsson, Anna G, 1968 (författare)
Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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2012
2012
Engelska.
Ingår i: European journal of endocrinology. - 1479-683X. ; 166:6, s. 1061-8
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Most patients who have been treated for craniopharyngioma (CP) are GH deficient (GHD). GH replacement therapy (GHRT) may stimulate tumour regrowth; and one of the concerns with long-term GHRT is the risk of tumour progression. Therefore, the objective was to study tumour progression in CP patients on long-term GHRT.Case-control study.The criteria for inclusion of cases were: i) GHD caused by CP; ii) GHRT >3 years; and iii) regular imaging. This resulted in 56 patients (mean age at diagnosis 25±16 years) with a mean duration of GHRT of 13.6±5.0 years. As controls, 70 CP patients who had not received GHRT were sampled with regard to follow-up, gender, age at diagnosis and initial radiation therapy (RT).The 10-year tumour progression-free survival rate (PFSR) for the entire population was 72%. There was an association (hazard ratio, P value) between PFSR and initial RT (0.13, 0.001) and residual tumour (3.2, 0.001). The 10-year PFSR was 88% for the GHRT group and 57% for the control group. Substitution with GHRT resulted in the following associations to PFSR: GHRT (0.57, 0.17), initial RT (0.16, <0.001), residual tumour (2.6, <0.01) and gender (0.57, 0.10). Adjusted for these factors, the 10-year PFSR was 85% for the GHRT group and 65% for the control group.In patients with CP, the most important prognostic factors for the PFSR were initial RT and residual tumour after initial treatment. Long-term GHRT did not affect the PFSR in patients with CP.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Adolescent
Adult
Case-Control Studies
Child
Craniopharyngioma
chemically induced
pathology
Disease Progression
Female
Follow-Up Studies
Hormone Replacement Therapy
adverse effects
Human Growth Hormone
administration & dosage
adverse effects
deficiency
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Recurrence
Local
chemically induced
Neoplasm
Residual
pathology
Pituitary Neoplasms
chemically induced
pathology
Proportional Hazards Models
Prospective Studies
Young Adult

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