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Incidence of malignant tumours in patients with a non-functioning pituitary adenoma.

Olsson, Daniel S, 1983 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Sahlgrenska University Hospital, Gothenburg, Sweden
Hammarstrand, Casper, 1990 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Sahlgrenska University Hospital, Gothenburg, Sweden
Bryngelsson, Ing-Liss (författare)
Region Örebro län,Department of Occupational and Environmental Medicine, Örebro University Hospital, Örebro, Sweden
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Nilsson, Anna G, 1968 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Sahlgrenska University Hospital, Gothenburg, Sweden
Andersson, Eva, 1955 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine,Department of Occupational and Environmental Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;Sahlgrenska University Hospital, Gothenburg, Sweden
Johannsson, Gudmundur, 1960 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Sahlgrenska University Hospital, Gothenburg, Sweden
Ragnarsson, Oskar, 1971 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Sahlgrenska University Hospital, Gothenburg, Sweden
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BioScientifica Ltd. 2017
2017
Engelska.
Ingår i: Endocrine-related cancer. - : BioScientifica Ltd.. - 1479-6821 .- 1351-0088. ; 24:5, s. 227-235
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Whether patients with non-functioning pituitary adenoma (NFPA) are at increased risk of developing malignant tumours has been sparsely studied and is a matter of debate. In this study, we have investigated the incidence of malignant tumours in a large and unselected group of patients with NFPA. The study was nationwide and included all patients diagnosed with NFPA between 1987-2011 (n=2,795) in Sweden, identified in the National Patient Register. Malignant tumours, occurring after the NFPA diagnosis, were identified in the Swedish Cancer Register between 1987-2014. Standardised incidence ratios (SIRs) for malignant tumours with 95% confidence intervals (CI) were calculated using the Swedish population as reference. In total, 448 malignant tumours were detected in 386 patients with NFPA, as compared to 368 expected malignancies in the general population [SIR 1.22 (95% CI 1.11-1.33)]. The incidence of neoplasms of the brain was increased [SIR 5.83 (95% CI 4.03-8.14)]. When analysing the total incidence of malignancies excluding neoplasms of the brain, the overall SIR was still increased [SIR 1.14 (95% CI 1.03-1.26)]. The incidence of malignant neoplasm of skin other than malignant melanoma [SIR 1.99 (95% CI 1.55-2.52)] and malignant melanoma [SIR 1.62 (95% CI 1.04-2.38)] were increased, whereas the incidence of breast cancer [SIR 0.65 (95% CI 0.42-0.97)] was decreased. The incidence of other types of malignancies did not differ significantly from the expected incidence in the general population. In conclusion, patients with NFPA have an increased over-all risk of developing malignancies. To what extent these findings are due to more frequent medical surveillance, genetic predisposition, or endocrine changes, remains unknown.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)

Nyckelord

non-functioning pituitary adenoma
malignant tumours
incidence
breast cancer
colorectal cancer
hypopituitarism
skin cancer

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