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The effects of baro...
The effects of baroreflex activation therapy on blood pressure and sympathetic function in patients with refractory hypertension: the rationale and design of the Nordic BAT study
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- Gordin, D. (författare)
- University of Helsinki
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Elmula, Femf (författare)
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- Andersson, Bert, 1952 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Gottsäter, Anders (författare)
- Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups,Skåne University Hospital
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- Elf, Johan (författare)
- Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups,Skåne University Hospital
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- Kahan, T. (författare)
- Karolinska Institute,Karolinska Institutet
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- Christensen, K. L. (författare)
- Aarhus University Hospital
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- Vikatmaa, P. (författare)
- Helsinki University Central Hospital
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- Vikatmaa, L. (författare)
- University of Helsinki
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- Olesen, T. B. (författare)
- Odense University Hospital
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- Groop, P. H. (författare)
- University of Helsinki
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- Olsen, M. H. (författare)
- Odense University Hospital
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- Tikkanen, I. (författare)
- Aarhus University Hospital
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Nordic, B. A. T. Study Grp (författare)
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- Fadl Elmula, Fadl Elmula M. (författare)
- Oslo university hospital
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(creator_code:org_t)
- 2017-06-08
- 2017
- Engelska.
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Ingår i: Blood Pressure. - : Informa UK Limited. - 0803-7051 .- 1651-1999. ; 26:5, s. 294-302
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Objective: To explore the effects of baroreflex activation therapy (BAT) on hypertension in patients with treatment resistant or refractory hypertension.Methods: This investigator-initiated randomized, double-blind, 1:1 parallel-design clinical trial will include 100 patients with refractory hypertension from 6 tertiary referral hypertension centers in the Nordic countries. A Barostim Neo System will be implanted and after 1 month patients will be randomized to either BAT for 16 months or continuous pharmacotherapy (BAT off) for 8 months followed by BAT for 8 months. A second randomization will take place after 16 months to BAT or BAT off for 3 months. Eligible patients have a daytime systolic ambulatory blood pressure (ABPM) of 145mm Hg, and/or a daytime diastolic ABPM of 95mm Hg after witnessed drug intake (including 3 antihypertensive drugs, preferably including a diuretic).Results: The primary end point is the reduction in 24-hour systolic ABPM by BAT at 8 months, as compared to pharmacotherapy. Secondary and tertiary endpoints are effects of BAT on home and office blood pressures, measures of indices of cardiac and vascular structure and function during follow-up, and safety.Conclusions: This academic initiative will increase the understanding of mechanisms and role of BAT in the refractory hypertension.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Ambulatory blood pressure measurement
- baroreflex sensitivity
- baroreflex activation therapy
- RHEOS PIVOTAL TRIAL
- RESISTANT HYPERTENSION
- HEART-FAILURE
- MANAGEMENT
- HEMODYNAMICS
- STIMULATION
- SYSTEM
- NERVE
- cardiac autonomic function
- diabetes
- heart rate variability
- myocardial infarction
- peripheral vascular disease
- refractory hypertension
- resistant hypertension
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Gordin, D.
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Elmula, Femf
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Andersson, Bert, ...
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Gottsäter, Ander ...
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Elf, Johan
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Kahan, T.
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visa fler...
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Christensen, K. ...
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Vikatmaa, P.
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Vikatmaa, L.
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Olesen, T. B.
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Groop, P. H.
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Olsen, M. H.
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Tikkanen, I.
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Nordic, B. A. T. ...
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Fadl Elmula, Fad ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Blood Pressure
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet
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Lunds universitet