SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:gup.ub.gu.se/257562"
 

Sökning: onr:"swepub:oai:gup.ub.gu.se/257562" > Polycystic ovary sy...

Polycystic ovary syndrome, personality, and depression: A twin study.

Cesta, Carolyn E (författare)
Kuja-Halkola, Ralf (författare)
Lehto, Kelli (författare)
visa fler...
Iliadou, Anastasia N (författare)
Landén, Mikael, 1966- (författare)
Göteborgs universitet, Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi, Gothenburg University, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Cesta, CE, (författare)
Karolinska Institutet
Kuja-Halkola, R, (författare)
Karolinska Institutet
Lehto, K, (författare)
Karolinska Institutet
Iliadou, AN, (författare)
Karolinska Institutet
Landen, M, (författare)
Karolinska Institutet
visa färre...
Göteborgs universitet Sahlgrenska akademin. Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi. 
2017
Engelska.
Ingår i: Psychoneuroendocrinology. - 1873-3360. ; 85, s. 63-68
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Women with polycystic ovary syndrome (PCOS) are at elevated risk for suffering from depression. Neuroticism is a personality trait that has been associated with an increased risk for developing major depressive disorder (MDD). The aim of the present study was to quantify and decompose the correlation between neuroticism, PCOS, and MDD into shared and unique genetic and environmental etiologies, by using quantitative genetic methods.In a cohort of 12,628 Swedish female twins born from 1959 to 1985, neuroticism, PCOS identified by symptoms of hyperandrogenemia (i.e., hirsutism) and oligo- and/or anovulation, and lifetime MDD status were determined through questionnaire responses. Structural equation modeling was used to study the genetic and environmental sources of the variation within, and covariation between neuroticism, PCOS, and MDD.Female twins with PCOS (n=752) had significantly higher levels of neuroticism than women without PCOS, and a 2-fold increase in odds for a lifetime prevalence of MDD. The phenotypic correlation between PCOS and MDD was 0.19, with 63% of the correlation attributable to common genetic factors between the two traits. When taking into account neuroticism, 41% was attributable to common genetic factors and 9% attributable to common environmental factors shared between all three traits, with the remainder attributable to components unique to PCOS and MDD.There are common genetic factors between neuroticism, PCOS, and MDD; however, neuroticism shares approximately half of the genetic and environmental components behind the phenotypic correlation between PCOS and MDD, providing some etiological evidence behind the comorbidity between PCOS and depression.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Publikations- och innehållstyp

art (ämneskategori)
ref (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy