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Effects of ventral ...
Effects of ventral striatal 6-OHDA lesions or amphetamine sensitization on ethanol consumption in the rat.
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- Fahlke, Claudia, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
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Hansen, S (författare)
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Engel, J A (författare)
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visa fler...
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Hård, E (författare)
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visa färre...
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(creator_code:org_t)
- 1994
- 1994
- Engelska.
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Ingår i: Pharmacology, biochemistry, and behavior. - 0091-3057. ; 47:2, s. 345-9
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- Female rats with continuous access to water and 6% ethanol were given bilateral ventral striatal 6-OHDA infusions, which induced pronounced striatal depletions of dopamine. The postoperative ethanol consumption of these rats was not significantly affected in comparison to vehicle-infused controls. In a second experiment, female rats received escalating doses of d-amphetamine over a 5-week period (from 1 to 9 mg/kg/injection). Control females were given saline injections. Following a 3-month drug-free interval, the females were given access to ethanol, the concentration of which was gradually increased from 2% to 12% with weekly intervals. Amphetamine-sensitized rats consumed significantly more alcohol than the saline-treated controls. Taken together, these results suggest that striatal dopaminergic mechanisms, while not necessary for basal ethanol drinking, can facilitate alcohol drinking.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Nyckelord
- Alcohol Drinking
- psychology
- Amphetamine
- pharmacology
- Animals
- Dopamine
- metabolism
- Female
- Motor Activity
- drug effects
- Neostriatum
- drug effects
- physiology
- Norepinephrine
- metabolism
- Oxidopamine
- toxicity
- Rats
- Rats
- Wistar
- Serotonin
- metabolism
- Stereotyped Behavior
- drug effects
- Synaptic Transmission
- drug effects
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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