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Sökning: onr:"swepub:oai:gup.ub.gu.se/59664" > Preventing osteopor...

Preventing osteoporotic fractures with antiresorptive therapy: implications of microarchitectural changes.

Boonen, Steven (författare)
Haentjens, P (författare)
Vandenput, Liesbeth, 1974- (författare)
Göteborgs universitet, Institutionen för invärtesmedicin, Avdelningen för internmedicin, Gothenburg University, Institute of Internal Medicine, Dept of Medicine
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Vanderschueren, Dirk (författare)
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Göteborgs universitet Sahlgrenska akademin. Institutionen för invärtesmedicin, Avdelningen för internmedicin. 
2004
Engelska.
Ingår i: Journal of internal medicine. - 0954-6820. ; 255:1, s. 1-12
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Prospective studies have demonstrated that low bone mass correlates well with increased risk of osteoporotic fractures at various skeletal sites. Trials have likewise confirmed that enhancing bone mass with antiresorptive therapy reduces fracture incidence in individuals at risk. However, correlation of bone mineral density (BMD) increases with therapeutic risk reduction has proved less consistent than correlation of BMD decreases with greater fracture risk in the untreated. Indeed, various analyses have indicated that - even during treatment with potent bisphosphonates like alendronate and risedronate - BMD changes from baseline account for <30% of the reduction in vertebral fractures in treated women. It is clearly, therefore, that factors other than BMD are involved in the reduction of fracture risk achieved by antiresorptive therapies. According to recent micro-computed tomography imaging and other studies, antiresorptive therapy can help rebuild the microarchitecture of bone as well as strengthen the materials that go into it. When treating individuals with osteoporosis, these microarchitectural changes contribute to the reduction of fracture risk achieved by antiresorptive therapies.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

Bone Density
physiology
Bone Regeneration
physiology
Bone Remodeling
physiology
Bone Resorption
prevention & control
Diphosphonates
therapeutic use
Female
Fractures
Spontaneous
etiology
physiopathology
prevention & control
Hormone Replacement Therapy
Humans
Osteoporosis
complications
pathology
physiopathology
Vitamin D
therapeutic use

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