SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:gup.ub.gu.se/70893"
 

Sökning: onr:"swepub:oai:gup.ub.gu.se/70893" > Changes in hemostas...

Changes in hemostasis during pediatric heart surgery: impact of a biocompatible heparin-coated perfusion system.

Jensen, Eva, (författare)
Göteborgs universitet, Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård, Gothenburg University, Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
Andréasson, Svenerik, (författare)
Göteborgs universitet, Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård, Gothenburg University, Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
Bengtsson, Anders, 1954- (författare)
Göteborgs universitet, Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård, Gothenburg University, Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
visa fler...
Berggren, Håkan, 1951- (författare)
Göteborgs universitet, Hjärt-kärlinstitutionen, Gothenburg University, Cardiovascular Institute
Ekroth, Rolf, 1944- (författare)
Göteborgs universitet, Hjärt-kärlinstitutionen, Gothenburg University, Cardiovascular Institute
Larsson, Lars E, (författare)
Göteborgs universitet, Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård, Gothenburg University, Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
Ouchterlony, John, (författare)
Göteborgs universitet, Institutionen för de kirurgiska disciplinerna, Gothenburg University, Institute of Surgical Sciences
visa färre...
Göteborgs universitet Sahlgrenska akademin. Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård. 
Göteborgs universitet Sahlgrenska akademin. Hjärt-kärlinstitutionen. 
visa fler...
Göteborgs universitet Sahlgrenska akademin. Institutionen för de kirurgiska disciplinerna. 
visa färre...
2004
Engelska.
Ingår i: The Annals of thoracic surgery. - 0003-4975. ; 77:3, s. 962-7
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: This study describes the response in hemostasis during open-heart surgery with cardiopulmonary bypass (CPB) in children (<== 10 kg) and tests the hypothesis that the use of a biocompatible perfusion system, in comparison with a conventional system, causes less hemostatic activation. METHODS: Prospective, randomized, controlled clinical study. Forty consecutive children <== 10 kg were included and divided into two groups: group bioc. (n = 19) treated with a fully heparin-coated system, centrifugal pump, and a closed circuit, and group conv. (n = 21) treated with an uncoated system, roller pump, and a hard shell venous reservoir. Concentrations of plasma thrombin-antithrombin (TAT), D-dimer, tissue plasminogen activator antigen (t-PA ag), and the complex consisting of tissue plasminogen activator and its inhibitor plasminogen activator inhibitor-1 (t-PA-PAI-1) were measured. RESULTS: The biochemical variables measured increased significantly in both groups during the study period. There was less activation of fibrinolysis during cardiopulmonary bypass (t-PA ag: p = 0.009) in patients treated with the biocompatible perfusion system than in patients treated with the conventional system. A trend in favor of the biocompatible system based on the D-dimer and TAT data (p = 0.07 for both measurements) was observed but no significant intergroup differences regarding these variables or t-PA-PAI-1 were found. CONCLUSIONS: Open-heart surgery with cardiopulmonary bypass in children (<== 10 kg) causes transient activation of the coagulation and fibrinolytic systems. This study demonstrates that the use of a biocompatible perfusion system results in a lower extent of activation of fibrinolysis during CPB than the use of a conventional system.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)

Nyckelord

Anticoagulants
Antithrombin III
Cardiac Surgical Procedures
Cardiopulmonary Bypass
instrumentation
Coated Materials
Biocompatible
Female
Fibrin Fibrinogen Degradation Products
analysis
Hemostasis
physiology
Heparin
Humans
Infant
Male
Peptide Hydrolases
blood
Perfusion
instrumentation
Plasminogen Activator Inhibitor 1
blood
Prospective Studies
Tissue Plasminogen Activator
blood

Publikations- och innehållstyp

art (ämneskategori)
ref (ämneskategori)
art (ämneskategori)
ref (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy