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Differential effects of sex hormones on peri- and endocortical bone surfaces in pubertal girls.

Wang, Qingju (författare)
Alén, Markku (författare)
Nicholson, Patrick H F (författare)
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Halleen, Jussi M (författare)
Alatalo, Sari L (författare)
Ohlsson, Claes, 1965- (författare)
Göteborgs universitet, Institutionen för medicin, avdelningen för invärtesmedicin, Gothenburg University, Institute of Medicine, Department of Internal Medicine
Suominen, Harri (författare)
Cheng, Sulin (författare)
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Göteborgs universitet Sahlgrenska akademin. Institutionen för medicin, avdelningen för invärtesmedicin. 
2006
Engelska.
Ingår i: The Journal of clinical endocrinology and metabolism. - 0021-972X. ; 91:1, s. 277-82
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • CONTEXT: The role of sex steroids in bone growth in pubertal girls is not yet clear. Bone biomarkers are indicators of bone metabolic activity, but their value in predicting bone quality has not been studied in growing girls. OBJECTIVE: This study examines the association of sex hormones and bone markers with bone geometry and density in pubertal girls. DESIGN: The study was designed as a 2-yr longitudinal study in pubertal girls. Measurements were performed at baseline and at 1- and 2-yr follow-ups. SETTING: The study was conducted in a university laboratory. PARTICIPANTS: A total of 258 10- to 13-yr-old healthy girls at the baseline participated. METHODS: Peripheral quantitative computed tomography was used to scan the left tibial shaft. Serum 17beta-estradiol (E2), testosterone (T), SHBG, osteocalcin (OC), bone-specific alkaline phosphatase, and tartrate-resistant acid phosphatase isoform 5b were assessed. Data were analyzed using hierarchical linear models with random effect. RESULTS: E2 was a positive predictor for total bone mineral density (BMD), cortical thickness, and a negative predictor for endocortical circumference but had no predictive value for total bone cross-sectional area or periosteal circumference. T was a positive predictor for total cross-sectional area and periosteal circumference as well as endocortical circumference, and a negative predictor for total BMD. OC was negatively correlated with cortical BMD (R2 = 0.325; P < 0.001). CONCLUSIONS: In pubertal girls, E2 and T have different influences on bone properties at the long bone shaft. The results suggest that, at the endocortical surface, E2 inhibits bone resorption during rapid growth, and later, after menarche, acts at higher concentrations to promote bone formation. At the periosteal surface, T promotes bone formation, whereas E2 does not affect it. In addition, OC might be used as a predictor of cortical BMD.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)

Nyckelord

Acid Phosphatase
blood
Adolescent
Alkaline Phosphatase
blood
Biological Markers
Bone Density
Bone Development
drug effects
Child
Estradiol
blood
Female
Gonadal Steroid Hormones
pharmacology
Humans
Isoenzymes
blood
Linear Models
Menarche
physiology
Osteocalcin
blood
Puberty
physiology
Sex Hormone-Binding Globulin
metabolism
Testosterone
blood
Tibia
anatomy & histology
growth & development

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