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Sökning: onr:"swepub:oai:gup.ub.gu.se/75202" > The COMT val158met ...

The COMT val158met polymorphism is associated with early pubertal development, height and cortical bone mass in girls.

Eriksson, Anna-Lena, 1971- (författare)
Göteborgs universitet, Institutionen för invärtesmedicin, Avdelningen för klinisk farmakologi, Gothenburg University, Institute of Internal Medicine, Dept of Clinical Pharmacology
Suuriniemi, Miia (författare)
Mahonen, Anitta (författare)
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Cheng, Sulin (författare)
Ohlsson, Claes, 1965- (författare)
Göteborgs universitet, Institutionen för invärtesmedicin, Avdelningen för internmedicin, Gothenburg University, Institute of Internal Medicine, Dept of Medicine
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Göteborgs universitet Sahlgrenska akademin. Institutionen för invärtesmedicin, Avdelningen för klinisk farmakologi. 
Göteborgs universitet Sahlgrenska akademin. Institutionen för invärtesmedicin, Avdelningen för internmedicin. 
2005
Engelska.
Ingår i: Pediatric research. - 0031-3998. ; 58:1, s. 71-7
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Estrogens are involved in accretion of bone mass during puberty. Catechol-O-Methyltransferase (COMT) is involved in the degradation of estrogens. In this cross-sectional study we investigated associations between the COMT val158met polymorphism, which results in a 60-75% difference in enzyme activity between the val (high activity = H) and the met (low activity = L) variant, and skeletal phenotypes in 246 healthy pre/early pubertal girls. Girls with COMT(LL) were 5.4 cm taller than COMT(HH) girls. Dual x-ray absorptiometry showed higher values of bone mineral content (BMC), and larger areas of total body, femur and spine in COMT(LL). Cortical BMC, measured by peripheral quantitative computerized tomography in the tibia, was 9.8% higher in COMT(LL) compared with COMT(HH). This was due to a larger cortical cross sectional area while the cortical volumetric bone mineral density was not associated with COMT genotype. COMT(LL) girls had higher serum levels of free estradiol and insulin like growth factor. Regression models indicated that COMT genotype exerted effects on skeletal growth mainly via a regulation of free estradiol, resulting in an affected pubertal development (Tanner staging). We propose that the COMT(LL) genotype results in higher free estradiol levels and earlier pubertal development, leading to an increased skeletal growth in pre/early pubertal girls. Possible consequences for the adult skeleton however can be determined only after cessation of growth.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)

Nyckelord

Absorptiometry
Photon
Body Composition
Body Height
Bone Density
Bone and Bones
metabolism
Catechol O-Methyltransferase
genetics
Child
Estradiol
metabolism
Estrogens
metabolism
Female
Genotype
Humans
Methionine
chemistry
Phenotype
Polymorphism
Genetic
Puberty
genetics
Regression Analysis
Tomography
X-Ray Computed
Valine
chemistry

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