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Gender differences in heritability of depressive symptoms in the elderly

Jansson, M (författare)
Gatz, M. (författare)
Berg, S. (författare)
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Johansson, Boo, (författare)
Göteborgs universitet, Psykologiska institutionen, Gothenburg University, Department of Psychology
Malmberg, B. (författare)
McClearn, G.E. (författare)
Schalling, M. (författare)
Pedersen, Nancy L. (författare)
Johansson, B (författare)
Pedersen, NL, (författare)
Karolinska Institutet
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Göteborgs universitet Samhällsvetenskapliga fakulteten. Psykologiska institutionen. 
2004
Engelska.
Ingår i: PSYCHOLOGICAL MEDICINE. - 0033-2917. ; 34:3, s. 471-479
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • BACKGROUND: The present study aimed to investigate the relative importance of genetic and environmental influences on depressive symptoms in the elderly. METHOD: Depressive symptoms were assessed through the Center for Epidemiological Studies-Depression (CES-D) scale. The CES-D scale was administered to 959 twin pairs (123 female MZs, 90 male MZs, 207 same-sex female DZs, 109 same-sex male DZs and 430 opposite-sex DZs) aged 50 years or older (mean age 72 years). A dichotomous depressed state variable was constructed based on CES-D cut-offs and self-reported use of antidepressant medication. Structural equation models were fitted to the data to dissect genetic and environmental variance components. RESULTS: The sex-specific heritability estimates for depressive symptoms were 14% for males and 29% for females and 23% when constrained to be equal for men and women. The prevalence of clinically significant depressive symptoms was 16% for men and 24% for women. Heritability estimates for the dichotomous depressed state measure were 7% for males and 49% for females in the full model and 33% when constrained to be equal. CONCLUSION: Our results suggest that depressive symptoms in the elderly are moderately heritable, with a higher heritability for women than men, although differences in heritability estimates were not statistically significant.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
SAMHÄLLSVETENSKAP  -- Psykologi (hsv//swe)
SOCIAL SCIENCES  -- Psychology (hsv//eng)

Nyckelord

population-ascertained subsamples
pilot swedish twin
older-adults
environmental-contributions
affective-illness
major depression
community
sample
women
genes

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