SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:gup.ub.gu.se/99362"
 

Sökning: onr:"swepub:oai:gup.ub.gu.se/99362" > Consensus paper of ...

Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: the role of CSF and blood analysis in the early and differential diagnosis of dementia.

Wiltfang, J (författare)
Lewczuk, P (författare)
Riederer, P (författare)
visa fler...
Grünblatt, E (författare)
Hock, C (författare)
Scheltens, P (författare)
Hampel, H (författare)
Vanderstichele, H (författare)
Iqbal, K (författare)
Galasko, D (författare)
Lannfelt, L (författare)
Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Geriatrics
Otto, M (författare)
Esselmann, H (författare)
Henkel, A W (författare)
Kornhuber, J (författare)
Blennow, Kaj, 1958 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institute of Clinical Neurosciences, Section of Experimental Neuroscience
Blennow, K (författare)
Grunblatt, E (författare)
visa färre...
 (creator_code:org_t)
 
visa fler...
 
visa färre...
2005
2005
Engelska.
Ingår i: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. - 1562-2975. ; 6:2, s. 69-84
  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
Stäng  
  • Aging of population, and increasing life expectancy result in an increasing number of patients with dementia. This symptom can be a part of a completely curable disease of the central nervous system (e.g, neuroinflammation), or a disease currently considered irreversible (e.g, Alzheimer's disease, AD). In the latter case, several potentially successful treatment approaches are being tested now, demanding reasonable standards of pre-mortem diagnosis. Cerebrospinal fluid and serum analysis (CSF/serum analysis), whereas routinely performed in neuroinflammatory diseases, still requires standardization to be used as an aid to the clinically based diagnosis of AD. Several AD-related CSF parameters (total tau, phosphorylated forms of tau, Abeta peptides, ApoE genotype, p97, etc.) tested separately or in a combination provide sensitivity and specificity in the range of 85%, the figure commonly expected from a good diagnostic tool. In this review, recently published reports regarding progress in neurochemical pre-mortem diagnosis of dementias are discussed with a focus on an early and differential diagnosis of AD. Novel perspectives offered by recently introduced technologies, e.g, fluorescence correlation spectroscopy (FCS) and surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) are briefly discussed.

Nyckelord

Aged
Alzheimer Disease
blood
cerebrospinal fluid
genetics
Amyloid beta-Protein Precursor
cerebrospinal fluid
Apolipoproteins E
genetics
Biological Markers
blood
cerebrospinal fluid
Consensus
Diagnosis
Differential
Genotype
Humans
Immunoblotting
Microtubule-Associated Proteins
metabolism
Neurons
metabolism
Phosphorylation
Spectrometry
Mass
Matrix-Assisted Laser Desorption-Ionization
Time Factors
tau Proteins
cerebrospinal fluid
Aged
Alzheimer Disease/blood/cerebrospinal fluid/genetics
Amyloid beta-Protein Precursor/cerebrospinal fluid
Apolipoproteins E/genetics
Biological Markers/blood/cerebrospinal fluid
Diagnosis; Differential
Microtubule-Associated Proteins/metabolism
Neurons/metabolism
Research Support; Non-U.S. Gov't
Spectrometry; Mass; Matrix-Assisted Laser Desorption-Ionization
tau Proteins/cerebrospinal fluid

Publikations- och innehållstyp

ref (ämneskategori)
for (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy