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Reproductive hormone levels predict changes in frailty status in community-dwelling older men : European male ageing study prospective data

Swiecicka, Agnieszka, (författare)
University of Manchester
Eendebak, Robert J.A.H., (författare)
University of Manchester
Lunt, Mark, (författare)
Christie NHS Foundation Trust
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O'Neill, Terence W., (författare)
Christie NHS Foundation Trust
Bartfai, György, (författare)
University of Szeged
Casanueva, Felipe F., (författare)
Complejo Hospitalario Universitario de Santiago
Forti, Gianni, (författare)
University of Florence
Giwercman, Aleksander, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Reproduktionsmedicin, Malmö, Reproductive medicine, Malmö, Skåne University Hospital
Han, Thang S., (författare)
Royal Holloway University of London, Great Ormond Street Hospital
Slowikowska-Hilczer, Jolanta, (författare)
Medical University of Lodz
Lean, Michael E.J., (författare)
University of Glasgow
Pendleton, Neil, (författare)
University of Manchester
Punab, Margus, (författare)
Tartu University Hospital
Vanderschueren, Dirk, (författare)
Catholic University of Leuven
Huhtaniemi, Ilpo T., (författare)
Imperial College London, University of Turku
Wu, Frederick C.W., (författare)
University of Manchester
Rutter, Martin K., (författare)
University of Manchester, Christie NHS Foundation Trust
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2018
Engelska 9 s.
Ingår i: Journal of Clinical Endocrinology and Metabolism. - Oxford University Press. - 0021-972X. ; 103:2, s. 701-709
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  • Context: Clinical sequelae of androgen deficiency share common features with frailty. Evidence supporting the role of androgens in the development of frailty is limited and conflicting. Objective: To determine associations between male reproductive hormones and prospective changes in frailty status. Design/Setting: A 4.3-year prospective cohort study of community-dwelling men participating in the European Male Ageing Study. Participants: A total of 3369 men aged 40 to 79 from eight European centers. Intervention: None. Main Outcome Measure: Frailty status was determined using frailty index (FI; n = 2278) and frailty phenotype (FP; n = 1980). Results: After adjusting for baseline frailty, age, center, and smoking, the risk ofworsening FI decreased with higher testosterone (T), free T, and dihydrotestosterone (DHT) [percentage change (95% confidence interval) in FI associated with 1 standard deviation higher hormone level: -3.0 (-5.9, -1.0) for total T; -3.9 (-6.8, -2.0) for free T; and -3.9 (-6.8, -2.0) forDHT]. After further adjustment for bodymass index, only free T remained a significant predictor of FI change. In fully adjusted models, higher luteinizing hormone and follicle-stimulating hormone were positively related to worsening FI only in men ,60 years, and higher estradiol predicted lower likelihood of improving FP [odds ratio: 0.68 (0.52, 0.88)]. Conclusions: These prospective data support the hypothesis that higher androgen levels may protect elderly men from worsening frailty. However, the causal nature of these relationships requires further investigation.Whereas raised gonadotropins inmen,60 yearsmight be an earlymarker of frailty, the role of estradiol in frailty needs further clarification.

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MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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