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Sökning: onr:"swepub:oai:lup.lub.lu.se:07701c08-cc3f-4fa2-8e06-06fdc79fecba" > Gender differences ...

Gender differences in autism spectrum disorders: Divergence among specific core symptoms

Beggiato, Anita, (författare)
Hôpital universitaire Robert-Debré, Pasteur Institute
Peyre, Hugo, (författare)
Hôpital universitaire Robert-Debré
Maruani, Anna, (författare)
Hôpital universitaire Robert-Debré, Pasteur Institute
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Scheid, Isabelle, (författare)
Pasteur Institute, Fondation FondaMental, Hôpital universitaire Robert-Debré
Råstam, Maria, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Lund, Department of Clinical Sciences, Lund, Sektion IV, Division IV, Barn- och ungdomspsykiatri, Child and Adolescent Psychiatry, Utvecklingsrelaterade störningar, affektiv sjukdom och ångestsyndrom i barn- och ungdomspsykiatri, Disorders in clinical child and adolescent psychiatry
Amsellem, Frederique, (författare)
Pasteur Institute, Hôpital universitaire Robert-Debré
Gillberg, Carina I, (författare)
University of Gothenburg
Leboyer, Marion, (författare)
Henri Mondor Hospital, Fondation FondaMental, Mondor Institute of Biomedical Research (Inserm U955)
Bourgeron, Thomas, (författare)
Paris Diderot University, Pasteur Institute
Gillberg, Christopher, (författare)
University College London, University of Gothenburg
Delorme, Richard, (författare)
Paris Diderot University, Fondation FondaMental, Hôpital universitaire Robert-Debré, Pasteur Institute
Rastam, Maria (författare)
Gillberg, I Carina, 1949- (författare)
Göteborgs universitet, Gillbergcentrum, Gothenburg University, Gillberg Neuropsychiatry Centre
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Lunds universitet Barn- och ungdomspsykiatri. (creator_code:org_t)
Lunds universitet Utvecklingsrelaterade störningar, affektiv sjukdom och ångestsyndrom i barn- och ungdomspsykiatri. (creator_code:org_t)
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Göteborgs universitet Sahlgrenska akademin. Gillbergcentrum. 
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2017
Engelska.
Ingår i: Autism Research. - John Wiley and Sons Inc.. - 1939-3806. ; 10:4, s. 680-689
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Community-based studies have consistently shown a sex ratio heavily skewed towards males in autism spectrum disorders (ASD). The factors underlying this predominance of males are largely unknown, but the way girls score on standardized categorical diagnostic tools might account for the underrecognition of ASD in girls. Despite the existence of different norms for boys and girls with ASD on several major screening tests, the algorithm of the Autism Diagnosis Interview-Revised (ADI-R) has not been reformulated. The aim of our study was to investigate which ADI-R items discriminate between males and females, and to evaluate their weighting in the final diagnosis of autism. We then conducted discriminant analysis (DA) on a sample of 594 probands including 129 females with ASD, recruited by the Paris Autism Research International Sibpair (PARIS) Study. A replication analysis was run on an independent sample of 1716 probands including 338 females with ASD, recruited through the Autism Genetics Resource Exchange (AGRE) program. Entering the raw scores for all ADI-R items as independent variables, the DA correctly classified 78.9% of males and 72.9% of females (P<0.001) in the PARIS cohort, and 72.2% of males and 68.3% of females (P<0.0001) in the AGRE cohort. Among the items extracted by the stepwise DA, four belonged to the ADI-R algorithm used for the final diagnosis of ASD. In conclusion, several items of the ADI-R that are taken into account in the diagnosis of autism significantly differentiates between males and females. The potential gender bias thus induced may participate in the underestimation of the prevalence of ASD in females.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

autism spectrum disorders; sex; gender; autism diagnosis interview-revised
autism diagnosis interview-revised; autism spectrum disorders; gender; sex

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