Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite : Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
International Agency for Research on Cancer, World Health Organization
Agudo, Antonio (författare)
Catalan Institute of Oncology
Duell, Eric J. (författare)
Catalan Institute of Oncology
Weiderpass, Elisabete (författare)
Karolinska Institutet,UiT The Arctic University of Norway, Tromsø,University of Helsinki,Folkhälsan Research Center,Cancer Registry of Norway, Institute of Population-Based Cancer Research
Overvad, Kim (författare)
Aarhus University
Tjønneland, Anne (författare)
Danish Cancer Society Research Center
Halkjær, Jytte (författare)
Danish Cancer Society Research Center
Boutron-Ruault, Marie Christine (författare)
University of Paris-Sud,University of Paris-Saclay,Institut Gustave Roussy
Carbonnel, Franck (författare)
University of Paris-Sud,Bicêtre Hospital,University of Paris-Saclay,Institut Gustave Roussy
Cervenka, Iris (författare)
Institut Gustave Roussy,University of Paris-Sud,University of Paris-Saclay
Boeing, Heiner (författare)
German Institute of Human Nutrition
Kaaks, Rudolf (författare)
German Cancer Research Centre
Kühn, Tilman (författare)
German Cancer Research Centre
Trichopoulou, Antonia (författare)
Hellenic Health Foundation, Athens
Martimianaki, Georgia (författare)
Hellenic Health Foundation, Athens
Karakatsani, Anna (författare)
Attikon University Hospital,Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
Pala, Valeria (författare)
Istituto Nazionale dei Tumori
Palli, Domenico (författare)
Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
Mattiello, Amalia (författare)
University of Naples Federico II
Tumino, Rosario (författare)
Civic and M.P Arezzo Hospital
Sacerdote, Carlotta (författare)
Citta' della Salute e della Scienza Hospital-University of Turin
Skeie, Guri (författare)
UiT The Arctic University of Norway, Tromsø
Rylander, Charlotta (författare)
UiT The Arctic University of Norway, Tromsø
Chirlaque López, María Dolores (författare)
Murcia Regional Health Council,University of Murcia,CIBER Epidemiology and Public Health (CIBERESP)
Sánchez, Maria Jose (författare)
Hospital Clínico Universitario San Cecilio,University of Granada,CIBER Epidemiology and Public Health (CIBERESP)
Ardanaz, Eva (författare)
Navarre Public Health Institute (ISPN),Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
Regnér, Sara (författare)
Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital
Stocks, Tanja (författare)
Lund University,Lunds universitet,Registerbaserad epidemiologi,Forskargrupper vid Lunds universitet,LUCC - Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Register-based epidemiology,Lund University Research Groups,LUCC - Lund University Cancer Centre,Other Strong Research Environments
Bueno-de-Mesquita, Bas (författare)
National Institute for Public Health and the Environment (RIVM),Imperial College London,University Medical Center Utrecht,University of Malaya
Vermeulen, Roel C.H. (författare)
Utrecht University,University Medical Center Utrecht
Aune, Dagfinn (författare)
Bjørknes University College,Oslo university hospital,Imperial College London
Tong, Tammy Y.N. (författare)
University of Oxford
Kliemann, Nathalie (författare)
International Agency for Research on Cancer, World Health Organization
Murphy, Neil (författare)
International Agency for Research on Cancer, World Health Organization
Chadeau-Hyam, Marc (författare)
Imperial College London
Gunter, Marc J. (författare)
International Agency for Research on Cancer, World Health Organization
Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox models. During a mean follow-up of 14 years, 220 esophageal adenocarcinomas (EA), 195 esophageal squamous cell carcinomas, 243 gastric cardia (GC) and 373 gastric noncardia (GNC) cancers were diagnosed. Body mass index (BMI) was associated with EA in men (BMI ≥30 vs. 18.5–25 kg/m2: HR = 1.94, 95% CI: 1.25–3.03) and women (HR = 2.66, 95% CI: 1.15–6.19); however, adjustment for waist-to-hip ratio (WHR) attenuated these associations. After mutual adjustment for BMI and HC, respectively, WHR and waist circumference (WC) were associated with EA in men (HR = 3.47, 95% CI: 1.99–6.06 for WHR >0.96 vs. <0.91; HR = 2.67, 95% CI: 1.52–4.72 for WC >98 vs. <90 cm) and women (HR = 4.40, 95% CI: 1.35–14.33 for WHR >0.82 vs. <0.76; HR = 5.67, 95% CI: 1.76–18.26 for WC >84 vs. <74 cm). WHR was also positively associated with GC in women, and WC was positively associated with GC in men. Inverse associations were observed between parity and EA (HR = 0.38, 95% CI: 0.14–0.99; >2 vs. 0) and age at first pregnancy and GNC (HR = 0.54, 95% CI: 0.32–0.91; >26 vs. <22 years); whereas bilateral ovariectomy was positively associated with GNC (HR = 1.87, 95% CI: 1.04–3.36). These findings support a role for hormonal pathways in upper gastrointestinal cancers.
Ämnesord
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)