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Sökning: onr:"swepub:oai:lup.lub.lu.se:0ed9bab1-cae4-4269-a606-390f5f859231" > Plasma Metabolome a...

  • Li, QianShriners Hospitals for Children, Tampa,University of South Florida,Farr Institute of Health Informatics Research,University of South Florida; Department of Sociology (författare)

Plasma Metabolome and Circulating Vitamins Stratified Onset Age of an Initial Islet Autoantibody and Progression to Type 1 Diabetes : the TEDDY Study

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • American Diabetes Association Inc.2021
  • 11 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:0ed9bab1-cae4-4269-a606-390f5f859231
  • https://lup.lub.lu.se/record/0ed9bab1-cae4-4269-a606-390f5f859231URI
  • https://doi.org/10.2337/db20-0696DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Children's plasma metabolome, especially lipidome reflects gene regulation and dietary exposures, heralding the development of islet autoantibodies (IA) and type 1 diabetes (T1D). The TEDDY study enrolled 8676 newborns by screening HLA-DR-DQ genotypes at six clinical centers in four countries; profiled metabolome and measured concentrations of ascorbic acid, 25-hydroxyvitamin D (25(OH)D), erythrocyte membrane fatty acids following birth until IA seroconversion under nested case-control design. We grouped children having an initial autoantibody only against insulin (IAA-first) or glutamic acid decarboxylase (GADA-first) by unsupervised clustering of temporal lipidome, identifying a subgroup of children having early onset of each initial autoantibody, i.e., IAA-first by 12 months and GADA-first by 21 months, consistent with population-wide early seroconversion age. Differential analysis showed that infants having reduced plasma ascorbic acid and cholesterol experienced IAA-first earlier, while early onset of GADA-first was preceded by reduced sphingomyelins at infancy. Plasma 25(OH)D prior to either autoantibody was lower in T1D progressors compared to non-progressors, with simultaneous lower diglycerides, lysophosphatidylcholines, triglycerides, alanine before GADA-first. Plasma ascorbic acid and 25(OH)D at infancy were lower in HLA-DR3/DR4 children among IA cases but not in matched controls, implying gene expression dysregulation of circulating vitamins as latent signals for IA or T1D progression.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Liu, XiangUniversity of South Florida; Department of Sociology (författare)
  • Yang, JiminUniversity of South Florida; Department of Sociology (författare)
  • Erlund, IrisFinnish National Institute for Health and Welfare (författare)
  • Lernmark, ÅkeLund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups(Swepub:lu)endo-ale (författare)
  • Hagopian, WilliamPacific Northwest Diabetes Research Institute (författare)
  • Rewers, MarianUniversity of Colorado-Denver (författare)
  • She, Jin-XiongAugusta University (författare)
  • Toppari, JormaTurku University Hospital (författare)
  • Ziegler, Anette-GJalisco Institute of Diabetes and Obesity Research SC (författare)
  • Akolkar, BeenaNational Institutes Of Health Clinical Center (författare)
  • Krischer, Jeffrey PUniversity of South Florida; Department of Sociology (författare)
  • Shriners Hospitals for Children, TampaUniversity of South Florida (creator_code:org_t)
  • TEDDY Study Group

Sammanhörande titlar

  • Ingår i:Diabetes: American Diabetes Association Inc.70:1, s. 282-2921939-327X

Internetlänk

Hitta via bibliotek

  • Diabetes (Sök värdpublikationen i LIBRIS)

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