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Sökning: onr:"swepub:oai:lup.lub.lu.se:175d02f9-2a64-4e68-a91c-c61b68b54b35" > Surgical Morbidity ...

Surgical Morbidity and Mortality From the Multicenter Randomized Controlled NeoRes II Trial : Standard Versus Prolonged Time to Surgery After Neoadjuvant Chemoradiotherapy for Esophageal Cancer

Nilsson, Klara (författare)
Karolinska Institutet,Karolinska University Hospital,Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Science, Intervention and Technology, Division of Surgery, Karolinska Institute, Stockholm, Sweden
Klevebro, Fredrik (författare)
Karolinska Institutet,Karolinska University Hospital,Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Science, Intervention and Technology, Division of Surgery, Karolinska Institute, Stockholm, Sweden
Rouvelas, Ioannis (författare)
Karolinska Institutet,Karolinska University Hospital,Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Science, Intervention and Technology, Division of Surgery, Karolinska Institute, Stockholm, Sweden
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Lindblad, Mats (författare)
Karolinska Institutet,Karolinska University Hospital,Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Science, Intervention and Technology, Division of Surgery, Karolinska Institute, Stockholm, Sweden
Szabo, Eva (författare)
Örebro universitet,Örebro University,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery
Halldestam, Ingvar (författare)
Linköping University Hospital,Department of Surgery, University Hospital of Linköping, Linköping, Sweden
Smedh, Ulrika (författare)
Sahlgrenska University Hospital,Department of Surgery, Sahlgrenska University Hospital, Gothenburg Sweden
Wallner, Bengt (författare)
Norrland University Hospital,Department of Surgical and Perioperative Sciences, Umeå University Hospital, Umeå, Sweden
Johansson, Jan (författare)
Skåne University Hospital,Department of Surgery, Skåne University Hospital, Lund, Sweden
Johnsen, Gjermund (författare)
St. Olav’s University Hospital,Department of Gastrointestinal Surgery, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway
Aahlin, Eirik Kjus (författare)
University Hospital of North Norway,Department of GI and HPB Surgery, University Hospital of Northern Norway, Tromsø, Norway
Johannessen, Hans Olaf (författare)
Oslo university hospital
Hjortland, Geir Olav (författare)
Oslo university hospital,Department of Oncology, Oslo University Hospital, Oslo, Norway
Bartella, Isabel (författare)
University of Cologne,Department of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany
Schröder, Wolfgang (författare)
University of Cologne,Department of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany
Bruns, Christiane (författare)
University of Cologne,Department of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany
Nilsson, Magnus (författare)
Karolinska Institutet,Karolinska University Hospital,Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Science, Intervention and Technology, Division of Surgery, Karolinska Institute, Stockholm, Sweden
Johannessen, Hans-Olaf (författare)
Department of Gastrointestinal Surgery, Oslo University Hospital, Oslo, Norway
Johansson, J (författare)
Bartella, I (författare)
Johannessen, HO (författare)
Aahlin, EK (författare)
Bruns, C (författare)
Lindblad, M (författare)
Smedh, U (författare)
Johnsen, G (författare)
Klevebro, F (författare)
Wallner, B (författare)
Rouvelas, I (författare)
Hjortland, GO (författare)
Nilsson, K (författare)
Schröder, W (författare)
Nilsson, M (författare)
Karolinska Institutet
Szabo, E (författare)
Halldestam, I (författare)
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 (creator_code:org_t)
Lippincott Williams & Wilkins, 2020
2020
Engelska 6 s.
Ingår i: Annals of Surgery. - : Lippincott Williams & Wilkins. - 1528-1140 .- 0003-4932. ; 272:5, s. 684-689
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • OBJECTIVE: To investigate if prolonged TTS after completed nCRT improves postoperative outcomes for esophageal and esophagogastric junction cancer. SUMMARY OF BACKGROUND DATA: TTS has traditionally been 4-6 weeks after completed nCRT. However, the optimal timing is not known. METHODS: A multicenter clinical trial was performed with randomized allocation of TTS of 4-6 or 10-12 weeks. The primary endpoint of this sub-study was overall postoperative complications defined as Clavien-Dindo grade II-V. Secondary endpoints included complication severity according to Clavien-Dindo grade IIIb-V, postoperative 90-day mortality, and length of hospital stay. The study was registered in Clinicaltrials.gov (NCT02415101). RESULTS: In total 249 patients were randomized. There were no significant differences between standard TTS and prolonged TTS with regard to overall incidence of complications Clavien-Dindo grade II-V (63.2% vs 72.6%, P = 0.134) or regarding Clavien-Dindo grade IIIb-V complications (31.6% vs 34.9%, P = 0.603). There were no statistically significant differences between standard and prolonged TTS regarding anastomotic leak (P = 0.596), conduit necrosis (P = 0.524), chyle leak (P = 0.427), pneumonia (P = 0.548), and respiratory failure (P = 0.723). In the standard TTS arm 5 patients (4.3%) died within 90 days of surgery, compared to 4 patients (3.8%) in the prolonged TTS arm (P = 1.0). Median length of hospital stay was 15 days in the standard TTS arm and 17 days in the prolonged TTS arm (P = 0.234). CONCLUSION: The timing of surgery after completed nCRT for carcinoma of the esophagus or esophagogastric junction, is not of major importance with regard to short-term postoperative outcomes.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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