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Sökning: onr:"swepub:oai:lup.lub.lu.se:184ffe04-deb3-47ad-b43c-030ddbb1e5c0" > Regional structural...

Regional structural hypo- and hyperconnectivity of frontal–striatal and frontal–thalamic pathways in behavioral variant frontotemporal dementia

Jakabek, David (författare)
University of Wollongong
Power, Brian D. (författare)
University of Notre Dame Australia,North Metropolitan Health Service
Macfarlane, Matthew D. (författare)
Illawarra Shoalhaven Local Health District,University of Wollongong
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Walterfang, Mark (författare)
University of Melbourne,Royal Melbourne Hospital
Velakoulis, Dennis (författare)
University of Melbourne,Royal Melbourne Hospital
van Westen, Danielle (författare)
Skåne University Hospital
Lätt, Jimmy (författare)
Lund University,Lunds universitet,MR Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
Nilsson, Markus (författare)
Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund University Bioimaging Center,MR Physics,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
Looi, Jeffrey C.L. (författare)
University of Melbourne,Royal Melbourne Hospital,Australian National University,Canberra Hospital
Santillo, Alexander F. (författare)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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 (creator_code:org_t)
Wiley-Blackwell, 2018
2018
Engelska 11 s.
Ingår i: Human Brain Mapping. - : Wiley-Blackwell. - 1065-9471. ; 39:10, s. 4083-4093
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Behavioral variant frontotemporal dementia (bvFTD) has been predominantly considered as a frontotemporal cortical disease, with limited direct investigation of frontal–subcortical connections. We aim to characterize the grey and white matter components of frontal–thalamic and frontal–striatal circuits in bvFTD. Twenty-four patients with bvFTD and 24 healthy controls underwent morphological and diffusion imaging. Subcortical structures were manually segmented according to published protocols. Probabilistic pathways were reconstructed separately from the dorsolateral, orbitofrontal and medial prefrontal cortex to the striatum and thalamus. Patients with bvFTD had smaller cortical and subcortical volumes, lower fractional anisotropy, and higher mean diffusivity metrics, which is consistent with disruptions in frontal–striatal–thalamic pathways. Unexpectedly, regional volumes of the striatum and thalamus connected to the medial prefrontal cortex were significantly larger in bvFTD (by 135% in the striatum, p =.032, and 217% in the thalamus, p =.004), despite smaller dorsolateral prefrontal cortex connected regional volumes (by 67% in the striatum, p =.002, and 65% in the thalamus, p =.020), and inconsistent changes in orbitofrontal cortex connected regions. These unanticipated findings may represent compensatory or maladaptive remodeling in bvFTD networks. Comparisons are made to other neuropsychiatric disorders suggesting a common mechanism of changes in frontal–subcortical networks; however, longitudinal studies are necessary to test this hypothesis.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

behavioral variant frontotemporal dementia
connectivity
DTI
MRI
probabilistic tractography

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ref (ämneskategori)
art (ämneskategori)

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