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Complications of im...
Complications of implantable cardioverter-defibrillator treatment in arrhythmogenic right ventricular cardiomyopathy
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- Christensen, Alex Hørby (författare)
- University of Copenhagen,Copenhagen University Hospital,Gentofte Hospital,Copenhagen Univ Hosp Herlev Gentofte, Denmark; Univ Copenhagen, Denmark; Rigshosp, Denmark
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- Platonov, Pyotr G. (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Lund Univ, Sweden; Lund Univ, Sweden
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- Svensson, Anneli (författare)
- Linköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Jensen, Henrik K. (författare)
- Aarhus University Hospital,Aarhus Univ Hosp, Denmark; Aarhus Univ Hosp, Denmark
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- Rootwelt-Norberg, Christine (författare)
- Norwegian Radium Hospital,University of Oslo,Oslo Univ Hosp, Norway; Univ Oslo, Norway
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- Dahlberg, Pia (författare)
- Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Sweden
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- Madsen, Trine (författare)
- Aalborg University Hospital,Aalborg Univ Hosp, Denmark
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- Frederiksen, Tanja Charlotte (författare)
- Aarhus University Hospital,Aarhus Univ Hosp, Denmark; Aarhus Univ Hosp, Denmark
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- Heliö, Tiina (författare)
- Helsinki University Central Hospital,University of Helsinki,Helsinki Univ Hosp, Finland; Univ Helsinki, Finland
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- Haugaa, Kristina H. (författare)
- Karolinska Institutet,Norwegian Radium Hospital,University of Oslo,Oslo Univ Hosp, Norway; Univ Oslo, Norway
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- Bundgaard, Henning (författare)
- University of Copenhagen,Copenhagen University Hospital,Univ Copenhagen, Denmark; Rigshosp, Denmark
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- Svendsen, Jesper H. (författare)
- Copenhagen University Hospital,University of Copenhagen,Univ Copenhagen, Denmark; Rigshosp, Denmark
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(creator_code:org_t)
- 2021-07-19
- 2022
- Engelska 7 s.
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Ingår i: Europace. - : Oxford University Press (OUP). - 1099-5129 .- 1532-2092. ; 24:2, s. 306-312
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Aims: Treatment with implantable cardioverter-defibrillators (ICD) is a cornerstone for prevention of sudden cardiac death in arrhythmogenic right ventricular cardiomyopathy (ARVC). We aimed at describing the complications associated with ICD treatment in a multinational cohort with long-term follow-up. Methods and results: The Nordic ARVC registry was established in 2010 and encompasses a large multinational cohort of ARVC patients, including their clinical characteristics, treatment, and events during follow-up. We included 299 patients (66% males, median age 41 years). During a median follow-up of 10.6 years, 124 (41%) patients experienced appropriate ICD shock therapy, 28 (9%) experienced inappropriate shocks, 82 (27%) had a complication requiring surgery (mainly lead-related, n = 75), and 99 (33%) patients experienced the combined endpoint of either an inappropriate shock or a surgical complication. The crude rate of first inappropriate shock was 3.4% during the first year after implantation but decreased after the first year and plateaued over time. Contrary, the risk of a complication requiring surgery was 5.5% the first year and remained high throughout the study period. The combined risk of any complication was 7.9% the first year. In multivariate cox regression, presence of atrial fibrillation/flutter was a risk factor for inappropriate shock (P < 0.05), whereas sex, age at implant, and device type were not (all P > 0.05). Conclusion: Forty-one percent of ARVC patients treated with ICD experienced potentially life-saving ICD therapy during long-term follow-up. A third of the patients experienced a complication during follow-up with lead-related complications constituting the vast majority.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Arrhythmogenic right ventricular cardiomyopathy
- Cardiomyopathy
- Complications
- Implantable cardioverter-defibrillator
- Ventricular arrhythmia
- Arrhythmogenic right ventricular cardiomyopathy; Cardiomyopathy; Ventricular arrhythmia; Implantable cardioverter-defibrillator; Complications
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Christensen, Ale ...
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Platonov, Pyotr ...
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Svensson, Anneli
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Jensen, Henrik K ...
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Rootwelt-Norberg ...
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Dahlberg, Pia
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Madsen, Trine
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Frederiksen, Tan ...
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Heliö, Tiina
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Haugaa, Kristina ...
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Bundgaard, Henni ...
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Svendsen, Jesper ...
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