Instituto Nacional de Ciencias Médicas y Nutrición
Sanchez-Guerrero, Jorge (författare)
University of Toronto,Toronto Western Hospital
Bernatsky, Sasha (författare)
McGill University
Clarke, Ann E. (författare)
University of Calgary
Wallace, Daniel J. (författare)
Cedars-Sinai Medical Center,University of California, Los Angeles
Isenberg, David A. (författare)
University College London
Rahman, Anisur (författare)
University College London
Merrill, Joan T. (författare)
Oklahoma Medical Research Foundation
Fortin, Paul (författare)
Centre hospitalier universitaire de Québec
Gladman, Dafna D. (författare)
Toronto Western Hospital,University of Toronto
Bruce, Ian N. (författare)
Central Manchester University Hospitals,University of Manchester
Petri, Michelle (författare)
Johns Hopkins University
Ginzler, Ellen M. (författare)
State University of New York Downstate Medical Center
Dooley, M. A. (författare)
University of North Carolina
Steinsson, Kristjan (författare)
National University Hospital of Iceland
Ramsey-Goldman, Rosalind (författare)
Northwestern University
Zoma, Asad A. (författare)
Hairmyres Hospital
Manzi, Susan (författare)
Allegheny Health Network
Nived, Ola (författare)
Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
Jonsen, Andreas (författare)
Lund University,Lunds universitet,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups
Khamashta, Munther A. (författare)
St Thomas' Hospital,King's College London
Alarcón, Graciela S. (författare)
University of Alabama
Chatham, Winn (författare)
University of Alabama
van Vollenhoven, Ronald F. (författare)
Karolinska Institutet
Aranow, Cynthia (författare)
Feinstein Institute for Medical Research
Mackay, Meggan (författare)
Feinstein Institute for Medical Research
Ruiz-Irastorza, Guillermo (författare)
University of the Basque Country,Gurutzeta/Cruces University Hospital
Ramos-Casals, Manuel (författare)
Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),Hospital Clínic of Barcelona
Objective: To determine the frequency, characteristics, and outcomes of cerebrovascular events (CerVEs), as well as clinical and autoantibody associations in a multiethnic/racial inception cohort of patients with systemic lupus erythematosus (SLE). Methods: A total of 1,826 patients were assessed annually for 19 neuropsychiatric (NP) events, including 5 types of CerVEs: 1) stroke, 2) transient ischemia, 3) chronic multifocal ischemia, 4) subarachnoid/intracranial hemorrhage, and 5) sinus thrombosis. Global disease activity (Systemic Lupus Erythematosus Disease [SLE] Activity Index 2000), damage scores (SLE International Collaborating Clinics/American College of Rheumatology Damage Index), and Short Form 36 (SF-36) scores were collected. Time to event, linear and logistic regressions, and multistate models were used as appropriate. Results: CerVEs were the fourth most frequent NP event: 82 of 1,826 patients had 109 events; of these events, 103 were attributed to SLE, and 44 were identified at the time of enrollment. The predominant events were stroke (60 of 109 patients) and transient ischemia (28 of 109 patients). CerVEs were associated with other NP events attributed to SLE, non–SLE-attributed NP events, African ancestry (at US SLICC sites), and increased organ damage scores. Lupus anticoagulant increased the risk of first stroke and sinus thrombosis and transient ischemic attack. Physician assessment indicated resolution or improvement in the majority of patients, but patients reported sustained reduction in SF-36 summary and subscale scores following a CerVE. Conclusion: CerVEs, the fourth most frequent NP event in SLE, are usually attributable to lupus. In contrast to good physician-reported outcomes, patients reported a sustained reduction in health-related quality of life following a CerVE.
Ämnesord
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)