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Sökning: onr:"swepub:oai:lup.lub.lu.se:2487f2ad-8be0-49c1-b3b2-9f1b72524992" > Circulating Monocyt...

Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke : Meta-Analysis of Population-Based Studies Involving 17 180 Individuals

Georgakis, Marios K. (författare)
University Hospital Munich,Ludwig-Maximilian University of Munich
Malik, Rainer (författare)
University Hospital Munich,Ludwig-Maximilian University of Munich
Björkbacka, Harry (författare)
Lund University,Lunds universitet,Kardiovaskulär forskning - cellulär metabolism och inflammation,Forskargrupper vid Lunds universitet,Cardiovascular Research - Cellular Metabolism and Inflammation,Lund University Research Groups
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Pana, Tiberiu Alexandru (författare)
University of Aberdeen
Demissie, Serkalem (författare)
Framingham Heart Study,Boston University
Ayers, Colby (författare)
University of Texas Southwestern Medical Center
Elhadad, Mohamed A. (författare)
German Centre for Cardiovascular Research,Helmholtz Zentrum München
Fornage, Myriam (författare)
University of Texas Health Science Centre
Beiser, Alexa S. (författare)
Framingham Heart Study,Boston University
Benjamin, Emelia J. (författare)
Boston University,Framingham Heart Study
Boekholdt, Matthijs S. (författare)
Academic Medical Center of University of Amsterdam (AMC)
Engström, Gunnar (författare)
Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
Herder, Christian (författare)
Heinrich Heine University Düsseldorf
Hoogeveen, Ron C. (författare)
Baylor College of Medicine
Koenig, Wolfgang (författare)
Technical University of Munich,German Centre for Cardiovascular Research,University of Ulm
Melander, Olle (författare)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Orho-Melander, Marju (författare)
Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
Schiopu, Alexandru (författare)
Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Skåne University Hospital
Söderholm, Martin (författare)
Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
Wareham, Nick (författare)
University of Cambridge
Ballantyne, Christie M. (författare)
Baylor College of Medicine
Peters, Annette (författare)
Helmholtz Zentrum München
Seshadri, Sudha (författare)
Boston University,University of Texas Health Science Centre,Framingham Heart Study
Myint, Phyo K. (författare)
University of Aberdeen
Nilsson, Jan (författare)
Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups
de Lemos, James A. (författare)
University of Texas Southwestern Medical Center
Dichgans, Martin (författare)
University Hospital Munich,German Center for Neurodegenerative Diseases (DZNE), Bonn,Munich Cluster for Systems Neurology
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 (creator_code:org_t)
American Heart Association, 2019
2019
Engelska 10 s.
Ingår i: Circulation Research. - : American Heart Association. - 0009-7330. ; 125:8, s. 773-782
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Rationale: Proinflammatory cytokines have been identified as potential targets for lowering vascular risk. Experimental evidence and Mendelian randomization suggest a role of MCP-1 (monocyte chemoattractant protein-1) in atherosclerosis and stroke. However, data from large-scale observational studies are lacking. Objective: To determine whether circulating levels of MCP-1 are associated with risk of incident stroke in the general population. Methods and Results: We used previously unpublished data on 17 180 stroke-free individuals (mean age, 56.7±8.1 years; 48.8% men) from 6 population-based prospective cohort studies and explored associations between baseline circulating MCP-1 levels and risk of any stroke, ischemic stroke, and hemorrhagic stroke during a mean follow-up interval of 16.3 years (280 522 person-years at risk; 1435 incident stroke events). We applied Cox proportional-hazards models and pooled hazard ratios (HRs) using random-effects meta-analyses. After adjustments for age, sex, race, and vascular risk factors, higher MCP-1 levels were associated with increased risk of any stroke (HR per 1-SD increment in ln-transformed MCP-1, 1.07; 95% CI, 1.01-1.14). Focusing on stroke subtypes, we found a significant association between baseline MCP-1 levels and higher risk of ischemic stroke (HR, 1.11 [1.02-1.21]) but not hemorrhagic stroke (HR, 1.02 [0.82-1.29]). The results followed a dose-response pattern with a higher risk of ischemic stroke among individuals in the upper quartiles of MCP-1 levels as compared with the first quartile (HRs, second quartile: 1.19 [1.00-1.42]; third quartile: 1.35 [1.14-1.59]; fourth quartile: 1.38 [1.07-1.77]). There was no indication for heterogeneity across studies, and in a subsample of 4 studies (12 516 individuals), the risk estimates were stable after additional adjustments for circulating levels of IL (interleukin)-6 and high-sensitivity CRP (C-reactive protein). Conclusions: Higher circulating levels of MCP-1 are associated with increased long-term risk of stroke. Our findings along with genetic and experimental evidence suggest that MCP-1 signaling might represent a therapeutic target to lower stroke risk.Visual Overview: An online visual overview is available for this article.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

atherosclerosis
cerebrovascular disorders
chemokine CCL2
inflammation
stroke

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