SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:lup.lub.lu.se:2a4905d8-8168-4458-b264-45f82fe1add0"
 

Sökning: onr:"swepub:oai:lup.lub.lu.se:2a4905d8-8168-4458-b264-45f82fe1add0" > Hypertension and ge...

Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols.

Padmanabhan, Sandosh (författare)
Melander, Olle (författare)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Hastie, Claire (författare)
visa fler...
Menni, Cristina (författare)
Delles, Christian (författare)
Connell, John M (författare)
Dominiczak, Anna F (författare)
visa färre...
 (creator_code:org_t)
Lippincott Williams & Wilkins, 2008
2008
Engelska.
Ingår i: Journal of Hypertension. - : Lippincott Williams & Wilkins. - 1473-5598. ; 26:7, s. 1275-1281
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Among the common complex diseases, hypertension has been particularly unlucky in the recent surge of positive results from genome-wide association studies. We summarize the evidence that would support continuing the effort in the hunt for a genetic basis for hypertension. The problems facing the genetic studies for hypertension are not unique, but phenotypic characterization, heterogeneity and high prevalence make it a special case requiring a more individualized approach. We argue that, even in the presence of a strong environmental component to hypertension risk, the common disease/common variant model is relevant for hypertension and discuss the issues involved in designing a genome-wide association study for hypertension. It is likely that the individual odds ratios for disease variants will be less than 1.3 and, although individually these effect sizes are minor, the combination of even a few such common polymorphisms can have substantial population attributable risks. The identification of hypertension gene variants should provide new insight into the disease susceptibility, progression and severity. This will lead to the identification of potential targets for lifestyle and pharmacological interventions, with the ultimate goal of improving prevention, diagnosis and treatment.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Sök utanför SwePub

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy