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Differences in genomic abnormalities among African individuals with monoclonal gammopathies using calculated ancestry

Baughn, Linda B, (författare)
Mayo Clinic Minnesota
Pearce, Kathryn, (författare)
Mayo Clinic Minnesota
Larson, Dirk, (författare)
Mayo Clinic Minnesota
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Polley, Mei-Yin, (författare)
Mayo Clinic Minnesota
Elhaik, Eran, (författare)
University of Sheffield
Baird, Michael, (författare)
DNA Diagnostics Center, Fairfield
Colby, Colin, (författare)
Mayo Clinic Minnesota
Benson, Joanne, (författare)
Mayo Clinic Minnesota
Li, Zhuo, (författare)
Mayo Clinic Minnesota
Asmann, Yan, (författare)
Mayo Clinic Minnesota
Therneau, Terry, (författare)
Mayo Clinic Minnesota
Cerhan, James R, (författare)
Mayo Clinic Minnesota
Vachon, Celine M, (författare)
Mayo Clinic Minnesota
Stewart, A Keith, (författare)
Mayo Clinic Scottsdale-Phoenix, Arizona, Mayo Clinic Minnesota
Bergsagel, P Leif, (författare)
Mayo Clinic Scottsdale-Phoenix, Arizona
Dispenzieri, Angela, (författare)
Mayo Clinic Minnesota
Kumar, Shaji, (författare)
Mayo Clinic Minnesota
Rajkumar, S Vincent, (författare)
Mayo Clinic Minnesota
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Engelska 10 s.
Ingår i: Blood Cancer Journal. - Nature Publishing Group. - 2044-5385. ; 8
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
  • Multiple myeloma (MM) is two- to three-fold more common in African Americans (AAs) compared to European Americans (EAs). This striking disparity, one of the highest of any cancer, may be due to underlying genetic predisposition between these groups. There are multiple unique cytogenetic subtypes of MM, and it is likely that the disparity is associated with only certain subtypes. Previous efforts to understand this disparity have relied on self-reported race rather than genetic ancestry, which may result in bias. To mitigate these difficulties, we studied 881 patients with monoclonal gammopathies who had undergone uniform testing to identify primary cytogenetic abnormalities. DNA from bone marrow samples was genotyped on the Precision Medicine Research Array and biogeographical ancestry was quantitatively assessed using the Geographic Population Structure Origins tool. The probability of having one of three specific subtypes, namely t(11;14), t(14;16), or t(14;20) was significantly higher in the 120 individuals with highest African ancestry (≥80%) compared with the 235 individuals with lowest African ancestry (<0.1%) (51% vs. 33%, respectively, p value = 0.008). Using quantitatively measured African ancestry, we demonstrate a major proportion of the racial disparity in MM is driven by disparity in the occurrence of the t(11;14), t(14;16), and t(14;20) types of MM.


African Continental Ancestry Group/genetics
Aged, 80 and over
Chromosome Aberrations
Chromosome Banding
Disease Progression
Gene Rearrangement
Genes, myc
Genetic Variation
In Situ Hybridization, Fluorescence
Middle Aged
Odds Ratio

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