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Sökning: onr:"swepub:oai:lup.lub.lu.se:419fe45d-c7f9-4429-97ab-c2cabe2bcd49" > Elevated luteinizin...

Elevated luteinizing hormone despite normal testosterone levels in older men-natural history, risk factors and clinical features

Eendebak, Robert J.A.H., (författare)
University of Manchester
Ahern, Tomas, (författare)
University of Manchester
Swiecicka, Agnieszka, (författare)
University of Manchester
visa fler...
Pye, Stephen R., (författare)
Christie NHS Foundation Trust
O'Neill, Terence W., (författare)
Christie NHS Foundation Trust
Bartfai, Gyorgy, (författare)
University of Szeged
Casanueva, Felipe F., (författare)
Complejo Hospitalario Universitario de Santiago
Maggi, Mario, (författare)
University of Florence
Forti, Gianni, (författare)
University of Florence
Giwercman, Aleksander, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Reproduktionsmedicin, Malmö, Reproductive medicine, Malmö
Han, Thang S., (författare)
Royal Holloway University of London
Słowikowska-Hilczer, Jolanta, (författare)
Medical University of Lodz
Lean, Michael E.J., (författare)
University of Glasgow
Punab, Margus, (författare)
Tartu University Hospital
Pendleton, Neil, (författare)
University of Manchester
Keevil, Brian G., (författare)
University Hospital of South Manchester NHS Foundation Trust
Vanderschueren, Dirk, (författare)
Catholic University of Leuven
Rutter, Martin K., (författare)
Christie NHS Foundation Trust
Tampubolon, Gindo, (författare)
University of Manchester
Goodacre, Royston, (författare)
University of Manchester
Huhtaniemi, Ilpo T., (författare)
University of Turku
Wu, Frederick C.W., (författare)
University of Manchester
visa färre...
2018
Engelska.
Ingår i: Clinical Endocrinology. - Wiley-Blackwell. - 0300-0664. ; 88:3, s. 479-490
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Objective: Elevated luteinizing hormone (LH) with normal testosterone (T) suggests compensated dysregulation of the gonadal axis. We describe the natural history, risk factors and clinical parameters associated with the development of high LH (HLH, LH >9.4 U/L) in ageing men with normal T (T ≥ 10.5 nmol/L). Design, Patients and Measurements: We conducted a 4.3-year prospective observational study of 3369 community-dwelling European men aged 40-79 years. Participants were classified as follows: incident (i) HLH (n = 101, 5.2%); persistent (p) HLH (n = 128, 6.6%); reverted (r) HLH (n = 46, 2.4%); or persistent normal LH (pNLH, n = 1667, 85.8%). Potential predictors and changes in clinical features associated with iHLH and rHLH were analysed using regression models. Results: Age >70 years (OR = 4.12 [2.07-8.20]), diabetes (OR = 2.86 [1.42-5.77]), chronic pain (OR = 2.53 [1.34-4.77]), predegree education (OR = 1.79 [1.01-3.20]) and low physical activity (PASE ≤ 78, OR = 2.37 [1.24-4.50]) predicted development of HLH. Younger age (40-49 years, OR = 8.14 [1.35-49.13]) and nonsmoking (OR = 5.39 [1.48-19.65]) predicted recovery from HLH. Men with iHLH developed erectile dysfunction, poor health, cardiovascular disease (CVD) and cancer more frequently than pNLH men. In pHLH men, comorbidities, including CVD, developed more frequently, and cognitive and physical function deteriorated more, than in pNLH men. Men with HLH developed primary hypogonadism more frequently (OR = 15.97 [5.85-43.60]) than NLH men. Men with rHLH experienced a small rise in BMI. Conclusions: Elevation of LH with normal T is predicted by multiple factors, reverts frequently and is not associated with unequivocal evidence of androgen deficiency. High LH is a biomarker for deteriorating health in aged men who tend to develop primary hypogonadism.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Other Medical Sciences -- Gerontology, specializing in Medical and Health Sciences (hsv//eng)

Nyckelord

Ageing
Hypogonadism
Luteinizing hormone
Physical function
Testosterone

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