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High complement fac...
High complement factor I activity in the plasma of children with autism spectrum disorders
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- Momeni, Naghi (författare)
- Linnéuniversitetet,Institutionen för naturvetenskap, NV
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- Brudin, Lars (författare)
- Kalmar County Hospital
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- Behnia, Fatemeh (författare)
- University of Social Welfare and rehabilitation Sciences, Iran
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- Nordström, Berit (författare)
- Lund University,Lunds universitet,Institutionen för hälsovetenskaper,Medicinska fakulteten,Barns och familjers hälsa,Forskargrupper vid Lunds universitet,Department of Health Sciences,Faculty of Medicine,Child and Family Health,Lund University Research Groups
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- Yousefi-Oudarji, Ali (författare)
- Tehran University of Medical Sciences, Iran
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- Sivberg, Bengt (författare)
- Lund University,Lunds universitet,Institutionen för hälsovetenskaper,Medicinska fakulteten,Hälsa i ett tvärvetenskapligt perspektiv,Forskargrupper vid Lunds universitet,Department of Health Sciences,Faculty of Medicine,Integrative Health Research,Lund University Research Groups
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- Joghataei, Mohammad (författare)
- Tehran University of Medical Sciences, Iran
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- Persson, Bengt L., 1951- (författare)
- Linnéuniversitetet,Institutionen för naturvetenskap, NV,Bengt Persson
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(creator_code:org_t)
- Hindawi Publishing Corporation, 2012
- 2012
- Engelska.
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Ingår i: Autism Research and Treatment. - : Hindawi Publishing Corporation. - 2090-1925 .- 2090-1933.
- Relaterad länk:
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https://doi.org/10.1...
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https://portal.resea... (primary) (free)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Autism spectrum disorders (ASDs) are neurodevelopmental and behavioural syndromes affecting social orientation, behaviour, and communication that can be classified as developmental disorders. ASD is also associated with immune system abnormality. Immune system abnormalities may be caused partly by complement system factor I deficiency. Complement factor I is a serine protease present in human plasma that is involved in the degradation of complement protein C3b, which is a major opsonin of the complement system. Deficiency in factor I activity is associated with an increased incidence of infections in humans. In this paper, we show that the mean level of factor I activity in the ASD group is significantly higher than in the control group of typically developed and healthy children, suggesting that high activity of complement factor I might have an impact on the development of ASD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Factor I
- Autism Spectrum Disorders
- ASD
- MEDICINE
- MEDICIN
- Biomedical Sciences
- Biomedicinsk vetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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