Harvard University,Brigham and Women's Hospital, Boston
Tjønneland, Anne (författare)
Danish Cancer Society Research Center
Hansen, Louise (författare)
Danish Cancer Society Research Center
Overvad, Kim (författare)
Aarhus University
Kvaskoff, Marina (författare)
University of Paris-Sud
Fournier, Agnes (författare)
University of Paris-Sud
Mancini, Francesca Romana (författare)
University of Paris-Sud
Boeing, Heiner (författare)
German Institute of Human Nutrition
Trichopoulou, Antonia (författare)
National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
Peppa, Eleni (författare)
Hellenic Health Foundation, Athens
Karakatsani, Anna (författare)
Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
Palli, Domenico (författare)
Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
Pala, Valeria (författare)
Istituto Nazionale dei Tumori
Mattiello, Amalia (författare)
University of Naples Federico II
Tumino, Rosario (författare)
Civic and M.P Arezzo Hospital
Grasso, Chiara C. (författare)
University of Turin
Onland-Moret, N. Charlotte (författare)
University Medical Center Utrecht
Weiderpass, Elisabete (författare)
Karolinska Institutet,University of Helsinki,Cancer Registry of Norway, Institute of Population-Based Cancer Research,UiT The Arctic University of Norway, Tromsø
Quiros, J. Ramon (författare)
Public Health Directorate
Lujan-Barroso, Leila (författare)
Bellvitge University Hospital-IDIBELL
Rodríguez-Barranco, Miguel (författare)
CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)
Colorado-Yohar, Sandra (författare)
University of Antioquia,Murcia Regional Health Council
Barricarte, Aurelio (författare)
Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
Dorronsoro, Miren (författare)
CIBER Epidemiology and Public Health (CIBERESP)
Idahl, Annika (författare)
Umeå universitet,Umeå University,Obstetrik och gynekologi,Näringsforskning
Lundin, Eva (författare)
Umeå universitet,Umeå University,Patologi
Sartor, Hanna (författare)
Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups,Skåne University Hospital
Khaw, Kay Tee (författare)
University of Cambridge
Key, Timothy J. (författare)
University of Oxford
Muller, David (författare)
Imperial College London
Riboli, Elio (författare)
International Agency for Research on Cancer, World Health Organization
Gunter, Marc J. (författare)
International Agency for Research on Cancer, World Health Organization
Dossus, Laure (författare)
International Agency for Research on Cancer, World Health Organization
Kaaks, Rudolf (författare)
German Cancer Research Centre
Cramer, Daniel W. (författare)
Brigham and Women's Hospital, Boston,Harvard University
Tworoger, Shelley S. (författare)
H. Lee Moffitt Cancer Center & Research Institute
Terry, Kathryn L. (författare)
Brigham and Women's Hospital, Boston,Harvard University
Background: Cancer antigen 125 (CA125) is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women. Methods: We evaluated predictors of CA125 levels among 815 premenopausal women from the New England Case Control Study (NEC). We developed linear and dichotomous (-35 U/mL) CA125 prediction models and externally validated an abridged model restricting to available predictors among 473 premenopausal women in the European Prospective Investigation into Cancer and Nutrition Study (EPIC). Results: The final linear CA125 prediction model included age, race, tubal ligation, endometriosis, menstrual phase at blood draw, and fibroids, which explained 7% of the total variance of CA125. The correlation between observed and predicted CA125 levels based on the abridged model (including age, race, and menstrual phase at blood draw) had similar correlation coefficients in NEC (r = 0.22) and in EPIC (r= 0.22). The dichotomous CA125 prediction model included age, tubal ligation, endometriosis, prior personal cancer diagnosis, family history of ovarian cancer, number of miscarriages, menstrual phase at blood draw, and smoking status with AUC of 0.83. The abridged dichotomous model (including age, number of miscarriages, menstrual phase at blood draw, and smoking status) showed similar AUCs in NEC (0.73) and in EPIC (0.78). Conclusions: We identified a combination of factors associated with CA125 levels in premenopausal women. Impact: Our model could be valuable in identifying healthy women likely to have elevated CA125 and consequently improve its specificity for ovarian cancer screening.
Ämnesord
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)