Predicting circulating CA125 levels among healthy premenopausal women

doi:10.1158/1055-9965.EPI-18-1120

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Predicting circulating CA125 levels among healthy premenopausal women

Sasamoto, Naoko, (författare): Brigham and Women's Hospital, Boston, Harvard University

Babic, Ana, (författare): Brigham and Women's Hospital, Boston, Harvard University, Dana-Farber Cancer Institute

Rosner, Bernard A., (författare): Brigham and Women's Hospital, Boston, Harvard University

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Fortner, Renee T., (författare): German Cancer Research Centre

Vitonis, Allison F., (författare): Brigham and Women's Hospital, Boston

Yamamoto, Hidemi, (författare): Brigham and Women's Hospital, Boston

Fichorova, Raina N., (författare): Brigham and Women's Hospital, Boston, Harvard University

Tjønneland, Anne, (författare): Danish Cancer Society Research Center

Hansen, Louise, (författare): Danish Cancer Society Research Center

Overvad, Kim, (författare): Aarhus University

Kvaskoff, Marina, (författare): University of Paris-Sud

Fournier, Agnes, (författare): University of Paris-Sud

Mancini, Francesca Romana, (författare): University of Paris-Sud

Boeing, Heiner, (författare): German Institute of Human Nutrition

Trichopoulou, Antonia, (författare): Hellenic Health Foundation, Athens, National and Kapodistrian University of Athens

Peppa, Eleni, (författare): Hellenic Health Foundation, Athens

Karakatsani, Anna, (författare): National and Kapodistrian University of Athens, Hellenic Health Foundation, Athens

Palli, Domenico, (författare): Institute for Cancer Research, Prevention and Clinical Network (ISPRO)

Pala, Valeria, (författare): Istituto Nazionale dei Tumori

Mattiello, Amalia, (författare): University of Naples Federico II

Tumino, Rosario, (författare): Civic and M.P Arezzo Hospital

Grasso, Chiara C., (författare): University of Turin

Onland-Moret, N. Charlotte, (författare): University Medical Center Utrecht

Weiderpass, Elisabete, (författare): UiT The Arctic University of Norway, Tromsø, Cancer Registry of Norway Institute of Population-Based Cancer Research, University of Helsinki, Karolinska Institutet

Quiros, J. Ramon, (författare): Public Health Directorate

Lujan-Barroso, Leila, (författare): Bellvitge University Hospital-IDIBELL

Rodríguez-Barranco, Miguel, (författare): CIBER Epidemiology and Public Health (CIBERESP), Andalusian School of Public Health

Colorado-Yohar, Sandra, (författare): Murcia Regional Health Council, University of Antioquia

Barricarte, Aurelio, (författare): CIBER Epidemiology and Public Health (CIBERESP), Health Research Institute of Navarra (IDISNA)

Dorronsoro, Miren, (författare): CIBER Epidemiology and Public Health (CIBERESP)

Idahl, Annika, (författare): Umeå University

Lundin, Eva, (författare): Umeå University

Sartor, Hanna, (författare): Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Diagnostisk radiologi, Malmö, Radiology Diagnostics, Malmö, Skåne University Hospital

Khaw, Kay Tee, (författare): University of Cambridge

Key, Timothy J., (författare): University of Oxford

Muller, David, (författare): Imperial College London

Riboli, Elio, (författare): International Agency for Research on Cancer, World Health Organization

Gunter, Marc J., (författare): International Agency for Research on Cancer, World Health Organization

Dossus, Laure, (författare): International Agency for Research on Cancer, World Health Organization

Kaaks, Rudolf, (författare): German Cancer Research Centre

Cramer, Daniel W., (författare): Harvard University, Brigham and Women's Hospital, Boston

Tworoger, Shelley S., (författare): H. Lee Moffitt Cancer Center & Research Institute

Terry, Kathryn L., (författare): Harvard University, Brigham and Women's Hospital, Boston

Tjonneland, Anne (författare)

Ramon Quiros, J. (författare)

Rodriguez-Barranco, Miguel (författare)

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Umeå universitet Medicinska fakulteten. Institutionen för klinisk vetenskap. Obstetrik och gynekologi. (creator_code:org_t)

Umeå universitet Medicinska fakulteten. Institutionen för folkhälsa och klinisk medicin. Näringsforskning. (creator_code:org_t)

2019
Engelska 10 s.
Ingår i: Cancer Epidemiology Biomarkers and Prevention. - American Association for Cancer Research. - 1055-9965. ; 28:6, s. 1076-1085

Relaterad länk:: http://dx.doi.org/10... (fulltext)

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Background: Cancer antigen 125 (CA125) is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women. Methods: We evaluated predictors of CA125 levels among 815 premenopausal women from the New England Case Control Study (NEC). We developed linear and dichotomous (-35 U/mL) CA125 prediction models and externally validated an abridged model restricting to available predictors among 473 premenopausal women in the European Prospective Investigation into Cancer and Nutrition Study (EPIC). Results: The final linear CA125 prediction model included age, race, tubal ligation, endometriosis, menstrual phase at blood draw, and fibroids, which explained 7% of the total variance of CA125. The correlation between observed and predicted CA125 levels based on the abridged model (including age, race, and menstrual phase at blood draw) had similar correlation coefficients in NEC (r = 0.22) and in EPIC (r= 0.22). The dichotomous CA125 prediction model included age, tubal ligation, endometriosis, prior personal cancer diagnosis, family history of ovarian cancer, number of miscarriages, menstrual phase at blood draw, and smoking status with AUC of 0.83. The abridged dichotomous model (including age, number of miscarriages, menstrual phase at blood draw, and smoking status) showed similar AUCs in NEC (0.73) and in EPIC (0.78). Conclusions: We identified a combination of factors associated with CA125 levels in premenopausal women. Impact: Our model could be valuable in identifying healthy women likely to have elevated CA125 and consequently improve its specificity for ovarian cancer screening.