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Sökning: onr:"swepub:oai:lup.lub.lu.se:4e7266cb-2f70-42de-a179-2a7be8896589" > Predicting circulat...

Predicting circulating CA125 levels among healthy premenopausal women

Sasamoto, Naoko, (författare)
Brigham and Women's Hospital, Boston, Harvard University
Babic, Ana, (författare)
Brigham and Women's Hospital, Boston, Harvard University, Dana-Farber Cancer Institute
Rosner, Bernard A., (författare)
Brigham and Women's Hospital, Boston, Harvard University
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Fortner, Renee T., (författare)
German Cancer Research Centre
Vitonis, Allison F., (författare)
Brigham and Women's Hospital, Boston
Yamamoto, Hidemi, (författare)
Brigham and Women's Hospital, Boston
Fichorova, Raina N., (författare)
Brigham and Women's Hospital, Boston, Harvard University
Tjønneland, Anne, (författare)
Danish Cancer Society Research Center
Hansen, Louise, (författare)
Danish Cancer Society Research Center
Overvad, Kim, (författare)
Aarhus University
Kvaskoff, Marina, (författare)
University of Paris-Sud
Fournier, Agnes, (författare)
University of Paris-Sud
Mancini, Francesca Romana, (författare)
University of Paris-Sud
Boeing, Heiner, (författare)
German Institute of Human Nutrition
Trichopoulou, Antonia, (författare)
Hellenic Health Foundation, Athens, National and Kapodistrian University of Athens
Peppa, Eleni, (författare)
Hellenic Health Foundation, Athens
Karakatsani, Anna, (författare)
National and Kapodistrian University of Athens, Hellenic Health Foundation, Athens
Palli, Domenico, (författare)
Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
Pala, Valeria, (författare)
Istituto Nazionale dei Tumori
Mattiello, Amalia, (författare)
University of Naples Federico II
Tumino, Rosario, (författare)
Civic and M.P Arezzo Hospital
Grasso, Chiara C., (författare)
University of Turin
Onland-Moret, N. Charlotte, (författare)
University Medical Center Utrecht
Weiderpass, Elisabete, (författare)
UiT The Arctic University of Norway, Tromsø, Cancer Registry of Norway Institute of Population-Based Cancer Research, University of Helsinki, Karolinska Institutet
Quiros, J. Ramon, (författare)
Public Health Directorate
Lujan-Barroso, Leila, (författare)
Bellvitge University Hospital-IDIBELL
Rodríguez-Barranco, Miguel, (författare)
CIBER Epidemiology and Public Health (CIBERESP), Andalusian School of Public Health
Colorado-Yohar, Sandra, (författare)
Murcia Regional Health Council, University of Antioquia
Barricarte, Aurelio, (författare)
CIBER Epidemiology and Public Health (CIBERESP), Health Research Institute of Navarra (IDISNA)
Dorronsoro, Miren, (författare)
CIBER Epidemiology and Public Health (CIBERESP)
Idahl, Annika, (författare)
Umeå University
Lundin, Eva, (författare)
Umeå University
Sartor, Hanna, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Diagnostisk radiologi, Malmö, Radiology Diagnostics, Malmö, Skåne University Hospital
Khaw, Kay Tee, (författare)
University of Cambridge
Key, Timothy J., (författare)
University of Oxford
Muller, David, (författare)
Imperial College London
Riboli, Elio, (författare)
International Agency for Research on Cancer, World Health Organization
Gunter, Marc J., (författare)
International Agency for Research on Cancer, World Health Organization
Dossus, Laure, (författare)
International Agency for Research on Cancer, World Health Organization
Kaaks, Rudolf, (författare)
German Cancer Research Centre
Cramer, Daniel W., (författare)
Harvard University, Brigham and Women's Hospital, Boston
Tworoger, Shelley S., (författare)
H. Lee Moffitt Cancer Center & Research Institute
Terry, Kathryn L., (författare)
Harvard University, Brigham and Women's Hospital, Boston
Tjonneland, Anne (författare)
Ramon Quiros, J. (författare)
Rodriguez-Barranco, Miguel (författare)
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Umeå universitet Medicinska fakulteten. Institutionen för klinisk vetenskap. Obstetrik och gynekologi. (creator_code:org_t)
Umeå universitet Medicinska fakulteten. Institutionen för folkhälsa och klinisk medicin. Näringsforskning. (creator_code:org_t)
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Umeå universitet Medicinska fakulteten. Institutionen för medicinsk biovetenskap. Patologi. (creator_code:org_t)
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2019
Engelska 10 s.
Ingår i: Cancer Epidemiology Biomarkers and Prevention. - American Association for Cancer Research. - 1055-9965. ; 28:6, s. 1076-1085
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Cancer antigen 125 (CA125) is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women. Methods: We evaluated predictors of CA125 levels among 815 premenopausal women from the New England Case Control Study (NEC). We developed linear and dichotomous (-35 U/mL) CA125 prediction models and externally validated an abridged model restricting to available predictors among 473 premenopausal women in the European Prospective Investigation into Cancer and Nutrition Study (EPIC). Results: The final linear CA125 prediction model included age, race, tubal ligation, endometriosis, menstrual phase at blood draw, and fibroids, which explained 7% of the total variance of CA125. The correlation between observed and predicted CA125 levels based on the abridged model (including age, race, and menstrual phase at blood draw) had similar correlation coefficients in NEC (r = 0.22) and in EPIC (r= 0.22). The dichotomous CA125 prediction model included age, tubal ligation, endometriosis, prior personal cancer diagnosis, family history of ovarian cancer, number of miscarriages, menstrual phase at blood draw, and smoking status with AUC of 0.83. The abridged dichotomous model (including age, number of miscarriages, menstrual phase at blood draw, and smoking status) showed similar AUCs in NEC (0.73) and in EPIC (0.78). Conclusions: We identified a combination of factors associated with CA125 levels in premenopausal women. Impact: Our model could be valuable in identifying healthy women likely to have elevated CA125 and consequently improve its specificity for ovarian cancer screening.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskaper -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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