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The incidence of Cushing’s disease : a nationwide Swedish study

Ragnarsson, Oskar (författare)
University of Gothenburg,Sahlgrenska University Hospital
Olsson, Daniel S. (författare)
University of Gothenburg,Sahlgrenska University Hospital
Chantzichristos, Dimitrios (författare)
University of Gothenburg,Sahlgrenska University Hospital
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Papakokkinou, Eleni (författare)
University of Gothenburg,Sahlgrenska University Hospital
Dahlqvist, Per (författare)
Umeå University
Segerstedt, Elin (författare)
Umeå University
Olsson, Tommy (författare)
Umeå University
Petersson, Maria (författare)
Karolinska Institutet,Karolinska University Hospital
Berinder, Katarina (författare)
Karolinska Institutet,Karolinska University Hospital
Bensing, Sophie (författare)
Karolinska Institutet,Karolinska University Hospital
Höybye, Charlotte (författare)
Karolinska Institutet,Karolinska University Hospital
Edén Engström, Britt (författare)
Uppsala University Hospital
Burman, Pia (författare)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skåne University Hospital
Bonelli, Lorenza (författare)
Skåne University Hospital,Lund University
Follin, Cecilia (författare)
Skåne University Hospital
Petranek, David (författare)
Skåne University Hospital
Erfurth, Eva Marie (författare)
Skåne University Hospital
Wahlberg, Jeanette (författare)
Linköping University
Ekman, Bertil (författare)
Linköping University
Åkerman, Anna Karin (författare)
Örebro University
Schwarcz, Erik (författare)
Örebro University
Bryngelsson, Ing Liss (författare)
Örebro University Hospital
Johannsson, Gudmundur (författare)
University of Gothenburg,Sahlgrenska University Hospital
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Springer, 2019-02-25
Ingår i: Pituitary. - : Springer. - 1386-341X. ; 22:2, s. 179-186
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
  • Background: Studies on the incidence of Cushing’s disease (CD) are few and usually limited by a small number of patients. The aim of this study was to assess the annual incidence in a nationwide cohort of patients with presumed CD in Sweden. Methods: Patients registered with a diagnostic code for Cushing’s syndrome (CS) or CD, between 1987 and 2013 were identified in the Swedish National Patient Registry. The CD diagnosis was validated by reviewing clinical, biochemical, imaging, and histopathological data. Results: Of 1317 patients identified, 534 (41%) had confirmed CD. One-hundred-and-fifty-six (12%) patients had other forms of CS, 41 (3%) had probable but unconfirmed CD, and 334 (25%) had diagnoses unrelated to CS. The mean (95% confidence interval) annual incidence between 1987 and 2013 of confirmed CD was 1.6 (1.4–1.8) cases per million. 1987–1995, 1996–2004, and 2005–2013, the mean annual incidence was 1.5 (1.1–1.8), 1.4 (1.0–1.7) and 2.0 (1.7–2.3) cases per million, respectively. During the last time period the incidence was higher than during the first and second time periods (P < 0.05). Conclusion: The incidence of CD in Sweden (1.6 cases per million) is in agreement with most previous reports. A higher incidence between 2005 and 2013 compared to 1987–2004 was noticed. Whether this reflects a truly increased incidence of the disease, or simply an increased awareness, earlier recognition, and earlier diagnosis can, however, not be answered. This study also illustrates the importance of validation of the diagnosis of CD in epidemiological research.


MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)


Cushing’s syndrome

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