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Sökning: onr:"swepub:oai:lup.lub.lu.se:591539c6-7d9e-4c4c-a3ec-174d8c4268b0" > The incidence of Cu...

  • Ragnarsson, OskarUniversity of Gothenburg,Sahlgrenska University Hospital (författare)

The incidence of Cushing’s disease : a nationwide Swedish study

  • Artikel/kapitelEngelska

Förlag, utgivningsår, omfång ...

  • Springer,2019-02-25


  • LIBRIS-ID:oai:lup.lub.lu.se:591539c6-7d9e-4c4c-a3ec-174d8c4268b0
  • https://lup.lub.lu.se/record/591539c6-7d9e-4c4c-a3ec-174d8c4268b0URI
  • https://doi.org/10.1007/s11102-019-00951-1DOI

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  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype


  • Background: Studies on the incidence of Cushing’s disease (CD) are few and usually limited by a small number of patients. The aim of this study was to assess the annual incidence in a nationwide cohort of patients with presumed CD in Sweden. Methods: Patients registered with a diagnostic code for Cushing’s syndrome (CS) or CD, between 1987 and 2013 were identified in the Swedish National Patient Registry. The CD diagnosis was validated by reviewing clinical, biochemical, imaging, and histopathological data. Results: Of 1317 patients identified, 534 (41%) had confirmed CD. One-hundred-and-fifty-six (12%) patients had other forms of CS, 41 (3%) had probable but unconfirmed CD, and 334 (25%) had diagnoses unrelated to CS. The mean (95% confidence interval) annual incidence between 1987 and 2013 of confirmed CD was 1.6 (1.4–1.8) cases per million. 1987–1995, 1996–2004, and 2005–2013, the mean annual incidence was 1.5 (1.1–1.8), 1.4 (1.0–1.7) and 2.0 (1.7–2.3) cases per million, respectively. During the last time period the incidence was higher than during the first and second time periods (P < 0.05). Conclusion: The incidence of CD in Sweden (1.6 cases per million) is in agreement with most previous reports. A higher incidence between 2005 and 2013 compared to 1987–2004 was noticed. Whether this reflects a truly increased incidence of the disease, or simply an increased awareness, earlier recognition, and earlier diagnosis can, however, not be answered. This study also illustrates the importance of validation of the diagnosis of CD in epidemiological research.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Olsson, Daniel S.University of Gothenburg,Sahlgrenska University Hospital (författare)
  • Chantzichristos, DimitriosUniversity of Gothenburg,Sahlgrenska University Hospital (författare)
  • Papakokkinou, EleniUniversity of Gothenburg,Sahlgrenska University Hospital (författare)
  • Dahlqvist, PerUmeå University (författare)
  • Segerstedt, ElinUmeå University (författare)
  • Olsson, TommyUmeå University (författare)
  • Petersson, MariaKarolinska Institutet,Karolinska University Hospital (författare)
  • Berinder, KatarinaKarolinska Institutet,Karolinska University Hospital (författare)
  • Bensing, SophieKarolinska Institutet,Karolinska University Hospital (författare)
  • Höybye, CharlotteKarolinska Institutet,Karolinska University Hospital (författare)
  • Edén Engström, BrittUppsala University Hospital (författare)
  • Burman, PiaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-bap (författare)
  • Bonelli, LorenzaLund University,Skåne University Hospital (författare)
  • Follin, CeciliaSkåne University Hospital(Swepub:lu)med-cfn (författare)
  • Petranek, DavidSkåne University Hospital (författare)
  • Erfurth, Eva MarieSkåne University Hospital(Swepub:lu)med-ee0 (författare)
  • Wahlberg, JeanetteLinköping University (författare)
  • Ekman, BertilLinköping University (författare)
  • Åkerman, Anna KarinÖrebro University (författare)
  • Schwarcz, ErikÖrebro University (författare)
  • Bryngelsson, Ing LissÖrebro University Hospital (författare)
  • Johannsson, GudmundurUniversity of Gothenburg,Sahlgrenska University Hospital (författare)
  • University of GothenburgSahlgrenska University Hospital (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Pituitary: Springer22:2, s. 179-1861386-341X


Hitta via bibliotek

  • Pituitary (Sök värdpublikationen i LIBRIS)

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