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LIBRIS Formathandbok  (Information om MARC21)
00005988naa a22009733a 4500
008080901s2012 xx |||| |0|| 0|eng d
024a 0003127748000132 isi
024a 231662092 pmid
024a 848738848962 scopus
024a 10.1161/CIRCGENETICS.112.9627872 doi
040 a (SwePub)lu
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
100a Smith, Gustav,u Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Lund, Department of Clinical Sciences, Lund, Sektion II, Section II, Kardiologi, Cardiology4 aut0 (SwePub:)
2451 0a The Impact of Ancestry and Common Genetic Variants on QT Interval in African Americans.
500 a Published
500 a 51
5208 enga BACKGROUND: -Ethnic differences in cardiac arrhythmia incidence have been reported, with a particularly high incidence of sudden cardiac death (SCD) and low incidence of atrial fibrillation in individuals of African ancestry. We tested the hypotheses that African ancestry and common genetic variants are associated with prolonged duration of cardiac repolarization, a central pathophysiological determinant of arrhythmia, as measured by the electrocardiographic QT interval. METHODS AND RESULTS: -First, individual estimates of African and European ancestry were inferred from genome-wide single nucleotide polymorphism (SNP) data in seven population-based cohorts of African Americans (n=12 097) and regressed on measured QT interval from electrocardiograms. Second, imputation was performed for 2.8 million SNPs and a genome-wide association (GWA) study of QT interval performed in ten cohorts (n=13 105). There was no evidence of association between genetic ancestry and QT interval (p=0.94). Genome-wide significant associations (p<2.5x10(-8)) were identified with SNPs at two loci, upstream of the genes NOS1AP (rs12143842, p=2x10(-15)) and ATP1B1 (rs1320976, p=2x10(-10)). The most significant SNP in NOS1AP was the same as the strongest SNP previously associated with QT interval in individuals of European ancestry. Low p-values (p<10(-5)) were observed for SNPs at several other loci previously identified in GWA studies in individuals of European ancestry, including KCNQ1, KCNH2, LITAF and PLN. CONCLUSIONS: -We observed no difference in duration of cardiac repolarization with global genetic indices of African ancestry. In addition, our GWA study extends the association of polymorphisms at several loci associated with repolarization in individuals of European ancestry to include African Americans.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi2 hsv//swe0 (SwePub)30206
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems2 hsv//eng0 (SwePub)30206
653 a electrophysiology
653 a electrocardiography
653 a genome-wide association studies
653 a ion channels
653 a repolarization
700a Avery, Christy L4 aut0 (SwePub:)
700a Evans, Daniel S4 aut0 (SwePub:)
700a Nalls, Michael A4 aut0 (SwePub:)
700a Meng, Yan A4 aut0 (SwePub:)
700a Smith, Erin N4 aut0 (SwePub:)
700a Palmer, Cameron4 aut0 (SwePub:)
700a Tanaka, Toshiko4 aut0 (SwePub:)
700a Mehra, Reena4 aut0 (SwePub:)
700a Butler, Anne M4 aut0 (SwePub:)
700a Young, Taylor4 aut0 (SwePub:)
700a Buxbaum, Sarah G4 aut0 (SwePub:)
700a Kerr, Kathleen F4 aut0 (SwePub:)
700a Berenson, Gerald S4 aut0 (SwePub:)
700a Schnabel, Renate B4 aut0 (SwePub:)
700a Guo, Li Jun4 aut0 (SwePub:)
700a Ellinor, Patrick T4 aut0 (SwePub:)
700a Magnani, Jared W4 aut0 (SwePub:)
700a Chen, Wei4 aut0 (SwePub:)
700a Bis, Joshua C4 aut0 (SwePub:)
700a Curb, J David4 aut0 (SwePub:)
700a Hsueh, Wen-Chi4 aut0 (SwePub:)
700a Rotter, Jerome I4 aut0 (SwePub:)
700a Liu, Yongmei4 aut0 (SwePub:)
700a Newman, Anne B4 aut0 (SwePub:)
700a Limacher, Marian C4 aut0 (SwePub:)
700a North, Kari E4 aut0 (SwePub:)
700a Reiner, Alexander P4 aut0 (SwePub:)
700a Quibrera, P Miguel4 aut0 (SwePub:)
700a Schork, Nicholas J4 aut0 (SwePub:)
700a Singleton, Andrew B4 aut0 (SwePub:)
700a Psaty, Bruce M4 aut0 (SwePub:)
700a Soliman, Elsayed Z4 aut0 (SwePub:)
700a Solomon, Allen J4 aut0 (SwePub:)
700a Srinivasan, Sathanur R4 aut0 (SwePub:)
700a Alonso, Alvaro4 aut0 (SwePub:)
700a Wallace, Robert4 aut0 (SwePub:)
700a Redline, Susan4 aut0 (SwePub:)
700a Zhang, Zhu-Ming4 aut0 (SwePub:)
700a Post, Wendy S4 aut0 (SwePub:)
700a Zonderman, Alan B4 aut0 (SwePub:)
700a Taylor, Herman A4 aut0 (SwePub:)
700a Murray, Sarah S4 aut0 (SwePub:)
700a Ferrucci, Luigi4 aut0 (SwePub:)
700a Arking, Dan E4 aut0 (SwePub:)
700a Evans, Michele K4 aut0 (SwePub:)
700a Fox, Ervin R4 aut0 (SwePub:)
700a Sotoodehnia, Nona4 aut0 (SwePub:)
700a Heckbert, Susan R4 aut0 (SwePub:)
700a Whitsel, Eric A4 aut0 (SwePub:)
700a Newton-Cheh, Christopher4 aut0 (SwePub:)
773t Circulation: Cardiovascular Geneticsd American Heart Associationx 1942-325Xg 5:6, s. 647-655q 5:6<647-655
8564 8u http://www.ncbi.nlm.nih.gov/pubmed/23166209?dopt=Abstractz fulltext
8564 8u http://dx.doi.org/10.1161/CIRCGENETICS.112.962787z fulltext
8564 8u https://lup.lub.lu.se/record/3218736y Till lärosätets (lu) databasx lärosäteslänk

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