SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:lup.lub.lu.se:6941c9cc-5ad4-48df-80fa-49908babf423"
 

Sökning: onr:"swepub:oai:lup.lub.lu.se:6941c9cc-5ad4-48df-80fa-49908babf423" > Cognitive Manic Sym...

Cognitive Manic Symptoms in Bipolar Disorder Associated with Polymorphisms in the DAOA and COMT Genes

Hukic, Dzana Sudic (författare)
Frisen, Louise (författare)
Backlund, Lena (författare)
visa fler...
Lavebratt, Catharina (författare)
Landen, Mikael (författare)
Träskman Bendz, Lil, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Lund, Department of Clinical Sciences, Lund, Sektion IV, Section IV, Psykiatri, Lund, Psychiatry (Lund)
Edman, Gunnar (författare)
Schalling, Martin (författare)
Osby, Urban (författare)
Frisén, Louise (författare)
Landén, Mikael, 1966- (författare)
Göteborgs universitet, Institutionen för neurovetenskap och fysiologi, Gothenburg University, Institute of Neuroscience and Physiology
Ösby, Urban (författare)
Hukic, DS, (författare)
Karolinska Institutet
Frisen, L, (författare)
Karolinska Institutet
Backlund, L, (författare)
Karolinska Institutet
Lavebratt, C, (författare)
Karolinska Institutet
Landen, M (författare)
Traskman-Bendz, L (författare)
Edman, G (författare)
Schalling, M, (författare)
Karolinska Institutet
Osby, U, (författare)
Karolinska Institutet
visa färre...
Göteborgs universitet Sahlgrenska akademin. Institutionen för neurovetenskap och fysiologi. 
2013
Engelska.
Ingår i: PLoS ONE. - Public Library of Science. - 1932-6203. ; 8:7
Läs hela texten (fulltext)
visa fler...
Läs hela texten (fulltext)
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Introduction: Bipolar disorder is characterized by severe mood symptoms including major depressive and manic episodes. During manic episodes, many patients show cognitive dysfunction. Dopamine and glutamate are important for cognitive processing, thus the COMT and DAOA genes that modulate the expression of these neurotransmitters are of interest for studies of cognitive function. Methodology: Focusing on the most severe episode of mania, a factor was found with the combined symptoms of talkativeness, distractibility, and thought disorder, considered a cognitive manic symptoms (CMS) factor. 488 patients were genotyped, out of which 373 (76%) had talkativeness, 269 (55%) distractibility, and 372 (76%) thought disorder. 215 (44%) patients were positive for all three symptoms, thus showing CMS (Table 1). As population controls, 1,044 anonymous blood donors (ABD) were used. Case-case and case-control design models were used to investigate genetic associations between cognitive manic symptoms in bipolar 1 disorder and SNPs in the COMT and DAOA genes. Results: The finding of this study was that cognitive manic symptoms in patients with bipolar 1 disorder was associated with genetic variants in the DAOA and COMT genes. Nominal association for DAOA SNPs and COMT SNPs to cognitive symptoms factor in bipolar 1 disorder was found in both allelic (Table 2) and haplotypic (Table 3) analyses. Genotypic association analyses also supported our findings. However, only one association, when CMS patients were compared to ABD controls, survived correction for multiple testing by max (T) permutation. Data also suggested interaction between SNPs rs2391191 in DAOA and rs5993883 in COMT in the case-control model. Conclusion: Identifying genes associated with cognitive functioning has clinical implications for assessment of prognosis and progression. Our finding are consistent with other studies showing genetic associations between the COMT and DAOA genes and impaired cognition both in psychiatric disorders and in the general population.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Publikations- och innehållstyp

art (ämneskategori)
ref (ämneskategori)

Hitta via bibliotek

  • PLoS ONE (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy