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Sökning: onr:"swepub:oai:lup.lub.lu.se:695f4695-1d31-42f2-8122-90df2d2620a0" > Second primary canc...

Second primary cancers in melanoma patients critically shorten survival

Zheng, Guoqiao, (författare)
German Cancer Research Centre, Heidelberg University
Chattopadhyay, Subhayan, (författare)
German Cancer Research Centre, Heidelberg University
Sundquist, Kristina, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Allmänmedicin och klinisk epidemiologi, Family Medicine and Clinical Epidemiology, Icahn School of Medicine at Mount Sinai, Shimane University
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Sundquist, Jan, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Allmänmedicin och klinisk epidemiologi, Family Medicine and Clinical Epidemiology, Shimane University, Icahn School of Medicine at Mount Sinai
Försti, Asta, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor, Family Medicine, Cardiovascular Epidemiology and Lifestyle, Allmänmedicin och klinisk epidemiologi, Family Medicine and Clinical Epidemiology, German Cancer Research Centre
Hemminki, Akseli, (författare)
Helsinki University of Technology, Helsinki University Central Hospital
Hemminki, Kari, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor, Family Medicine, Cardiovascular Epidemiology and Lifestyle, Charles University in Prague, German Cancer Research Centre
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2020
Engelska 8 s.
Ingår i: Clinical Epidemiology. - Dove Press. - 1179-1349. ; 12, s. 105-112
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  • Background: Survival in malignant cutaneous melanoma has improved but increasing survival will result in an increased likelihood of the occurrence of second primary cancers (SPCs). SPCs may adversely interfere with survival. We quantified survival in patients with different types of SPCs, in comparison to known poor prognostic indicators of metastatic disease. Methods: Data for melanoma and any SPCs were obtained from the Swedish Cancer Registry for years 2003 through 2015, including clinical TNM classification. SPCs were grouped into three ‘prognostic groups’ based on 5-year relative survival of these cancers as first primary cancer. Kaplan-Meier survival curves were generated and hazard ratios were estimated using Cox regression, adjusted for a number of variables and treating diagnosis of SPC as a time-dependent variable. Results: The total number of first melanoma patients was 28,716 followed by 3,202 (11.1%) SPCs, 1/3 of which had a second melanoma while 2/3 had other SPCs. Among men diagnosed at age over 70 years, who survived at least 10 years, 31.4% had SPC. HRs (95% CI) for survival increased systematically from the reference rate of 1.00 (no SPC) to 1.59 (1.35–1.87) with SPC of good prognosis (78.6% of SPCs) to 3.49 (2.58–4.72) of moderate prognosis (12.0%) and to 7.93 (5.50–11.44) of poor prognosis (9.4%). In patients without SPC, the HRs increased to 2.62 (2.02–3.39) with any nodal metastases and to 5.88 (4.57–7.57) with any distant metastases compared to patients without local or distant metastases. Conclusion: The data showed that SPCs are an increasingly common negative prognostic factor for melanoma. Future attempts to improve melanoma survival need to target SPCs.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Melanoma
Metastasis
Prognosis
Second cancer
Survival

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