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Sökning: onr:"swepub:oai:lup.lub.lu.se:774b8a1a-6956-4d8e-9462-d0ba634198bb" > Oral Contraceptive ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005571naa a2200961 4500
001oai:lup.lub.lu.se:774b8a1a-6956-4d8e-9462-d0ba634198bb
003SwePub
008200128| | |||||||||||000 ||eng|
024a https://lup.lub.lu.se/record/774b8a1a-6956-4d8e-9462-d0ba634198bb2 URI
024a https://doi.org/10.1093/jncics/pky0232 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Schrijver, Lieske H4 aut
2451 0a Oral Contraceptive Use and Breast Cancer Risk : Retrospective and Prospective Analyses From a BRCA1 and BRCA2 Mutation Carrier Cohort Study
264 1b Oxford University Press,c 2018-04
520 a Background: For BRCA1 and BRCA2 mutation carriers, the association between oral contraceptive preparation (OCP) use and breast cancer (BC) risk is still unclear.Methods: Breast camcer risk associations were estimated from OCP data on 6030 BRCA1 and 3809 BRCA2 mutation carriers using age-dependent Cox regression, stratified by study and birth cohort. Prospective, left-truncated retrospective and full-cohort retrospective analyses were performed.Results: For BRCA1 mutation carriers, OCP use was not associated with BC risk in prospective analyses (hazard ratio [HR] = 1.08, 95% confidence interval [CI] = 0.75 to 1.56), but in the left-truncated and full-cohort retrospective analyses, risks were increased by 26% (95% CI = 6% to 51%) and 39% (95% CI = 23% to 58%), respectively. For BRCA2 mutation carriers, OCP use was associated with BC risk in prospective analyses (HR = 1.75, 95% CI = 1.03 to 2.97), but retrospective analyses were inconsistent (left-truncated: HR = 1.06, 95% CI = 0.85 to 1.33; full cohort: HR = 1.52, 95% CI = 1.28 to 1.81). There was evidence of increasing risk with duration of use, especially before the first full-term pregnancy (BRCA1: both retrospective analyses, P < .001 and P = .001, respectively; BRCA2: full retrospective analysis, P = .002).Conclusions: Prospective analyses did not show that past use of OCP is associated with an increased BC risk for BRCA1 mutation carriers in young middle-aged women (40-50 years). For BRCA2 mutation carriers, a causal association is also not likely at those ages. Findings between retrospective and prospective analyses were inconsistent and could be due to survival bias or a true association for younger women who were underrepresented in the prospective cohort. Given the uncertain safety of long-term OCP use for BRCA1/2 mutation carriers, indications other than contraception should be avoided and nonhormonal contraceptive methods should be discussed.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
700a Olsson, Håkanu Skåne University Hospital4 aut0 (Swepub:lu)onk-hol
700a Phillips, Kelly-Anne4 aut
700a Terry, Mary Beth4 aut
700a Goldgar, David E4 aut
700a Kast, Karin4 aut
700a Engel, Christoph4 aut
700a Mooij, Thea M4 aut
700a Adlard, Julian4 aut
700a Barrowdale, Daniel4 aut
700a Davidson, Rosemarie4 aut
700a Eeles, Ros4 aut
700a Ellis, Steve4 aut
700a Evans, D Gareth4 aut
700a Frost, Debra4 aut
700a Izatt, Louise4 aut
700a Porteous, Mary E4 aut
700a Side, Lucy E4 aut
700a Walker, Lisa4 aut
700a Berthet, Pascaline4 aut
700a Bonadona, Valérie4 aut
700a Leroux, Dominique4 aut
700a Mouret-Fourme, Emmanuelle4 aut
700a Venat-Bouvet, Laurence4 aut
700a Buys, Saundra S4 aut
700a Southey, Melissa C4 aut
700a John, Esther M4 aut
700a Chung, Wendy K4 aut
700a Daly, Mary B4 aut
700a Bane, Anitau Karolinska University Hospital4 aut
700a van Asperen, Christi Ju Leiden University Medical Centre4 aut
700a Gómez Garcia, Encarna B4 aut
700a Mourits, Marian J E4 aut
700a van Os, Theo A M4 aut
700a Roos-Blom, Marie-José4 aut
700a Friedlander, Michael L4 aut
700a McLachlan, Sue-Anne4 aut
700a Singer, Christian F4 aut
700a Tan, Yen Y4 aut
700a Foretova, Lenka4 aut
700a Navratilova, Marie4 aut
700a Gerdes, Anne-Marie4 aut
700a Caldes, Trinidad4 aut
700a Simard, Jacques4 aut
700a Olah, Edith4 aut
700a Jakubowska, Anna4 aut
700a Arver, Britau Karolinska University Hospital4 aut
700a Osorio, Ana4 aut
700a Noguès, Catherine4 aut
700a Andrieu, Nadine4 aut
710a Skåne University Hospitalb Karolinska University Hospital4 org
710a EMBRACE
710a GENEPSO
710a BCFR
710a HEBON
710a kConFab
710a IBCCS
773t JNCI Cancer Spectrumd : Oxford University Pressg 2:2q 2:2x 2515-5091
856u http://dx.doi.org/10.1093/jncics/pky023x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/774b8a1a-6956-4d8e-9462-d0ba634198bb
8564 8u https://doi.org/10.1093/jncics/pky023

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