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Sökning: onr:"swepub:oai:lup.lub.lu.se:774b8a1a-6956-4d8e-9462-d0ba634198bb" > Oral Contraceptive ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005571naa a2200961 4500
001oai:lup.lub.lu.se:774b8a1a-6956-4d8e-9462-d0ba634198bb
003SwePub
008200128| | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/774b8a1a-6956-4d8e-9462-d0ba634198bb2 URI
0247 a https://doi.org/10.1093/jncics/pky0232 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Schrijver, Lieske H4 aut
2451 0a Oral Contraceptive Use and Breast Cancer Risk : Retrospective and Prospective Analyses From a BRCA1 and BRCA2 Mutation Carrier Cohort Study
264 1b Oxford University Press,c 2018-04
520 a Background: For BRCA1 and BRCA2 mutation carriers, the association between oral contraceptive preparation (OCP) use and breast cancer (BC) risk is still unclear.Methods: Breast camcer risk associations were estimated from OCP data on 6030 BRCA1 and 3809 BRCA2 mutation carriers using age-dependent Cox regression, stratified by study and birth cohort. Prospective, left-truncated retrospective and full-cohort retrospective analyses were performed.Results: For BRCA1 mutation carriers, OCP use was not associated with BC risk in prospective analyses (hazard ratio [HR] = 1.08, 95% confidence interval [CI] = 0.75 to 1.56), but in the left-truncated and full-cohort retrospective analyses, risks were increased by 26% (95% CI = 6% to 51%) and 39% (95% CI = 23% to 58%), respectively. For BRCA2 mutation carriers, OCP use was associated with BC risk in prospective analyses (HR = 1.75, 95% CI = 1.03 to 2.97), but retrospective analyses were inconsistent (left-truncated: HR = 1.06, 95% CI = 0.85 to 1.33; full cohort: HR = 1.52, 95% CI = 1.28 to 1.81). There was evidence of increasing risk with duration of use, especially before the first full-term pregnancy (BRCA1: both retrospective analyses, P < .001 and P = .001, respectively; BRCA2: full retrospective analysis, P = .002).Conclusions: Prospective analyses did not show that past use of OCP is associated with an increased BC risk for BRCA1 mutation carriers in young middle-aged women (40-50 years). For BRCA2 mutation carriers, a causal association is also not likely at those ages. Findings between retrospective and prospective analyses were inconsistent and could be due to survival bias or a true association for younger women who were underrepresented in the prospective cohort. Given the uncertain safety of long-term OCP use for BRCA1/2 mutation carriers, indications other than contraception should be avoided and nonhormonal contraceptive methods should be discussed.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
7001 a Olsson, Håkanu Skåne University Hospital4 aut0 (Swepub:lu)onk-hol
7001 a Phillips, Kelly-Anne4 aut
7001 a Terry, Mary Beth4 aut
7001 a Goldgar, David E4 aut
7001 a Kast, Karin4 aut
7001 a Engel, Christoph4 aut
7001 a Mooij, Thea M4 aut
7001 a Adlard, Julian4 aut
7001 a Barrowdale, Daniel4 aut
7001 a Davidson, Rosemarie4 aut
7001 a Eeles, Ros4 aut
7001 a Ellis, Steve4 aut
7001 a Evans, D Gareth4 aut
7001 a Frost, Debra4 aut
7001 a Izatt, Louise4 aut
7001 a Porteous, Mary E4 aut
7001 a Side, Lucy E4 aut
7001 a Walker, Lisa4 aut
7001 a Berthet, Pascaline4 aut
7001 a Bonadona, Valérie4 aut
7001 a Leroux, Dominique4 aut
7001 a Mouret-Fourme, Emmanuelle4 aut
7001 a Venat-Bouvet, Laurence4 aut
7001 a Buys, Saundra S4 aut
7001 a Southey, Melissa C4 aut
7001 a John, Esther M4 aut
7001 a Chung, Wendy K4 aut
7001 a Daly, Mary B4 aut
7001 a Bane, Anitau Karolinska University Hospital4 aut
7001 a van Asperen, Christi Ju Leiden University Medical Centre4 aut
7001 a Gómez Garcia, Encarna B4 aut
7001 a Mourits, Marian J E4 aut
7001 a van Os, Theo A M4 aut
7001 a Roos-Blom, Marie-José4 aut
7001 a Friedlander, Michael L4 aut
7001 a McLachlan, Sue-Anne4 aut
7001 a Singer, Christian F4 aut
7001 a Tan, Yen Y4 aut
7001 a Foretova, Lenka4 aut
7001 a Navratilova, Marie4 aut
7001 a Gerdes, Anne-Marie4 aut
7001 a Caldes, Trinidad4 aut
7001 a Simard, Jacques4 aut
7001 a Olah, Edith4 aut
7001 a Jakubowska, Anna4 aut
7001 a Arver, Britau Karolinska University Hospital4 aut
7001 a Osorio, Ana4 aut
7001 a Noguès, Catherine4 aut
7001 a Andrieu, Nadine4 aut
7102 a Skåne University Hospitalb Karolinska University Hospital4 org
7102 a EMBRACE
7102 a GENEPSO
7102 a BCFR
7102 a HEBON
7102 a kConFab
7102 a IBCCS
7730 t JNCI Cancer Spectrumd : Oxford University Pressg 2:2q 2:2x 2515-5091
8564 u http://dx.doi.org/10.1093/jncics/pky023x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/774b8a1a-6956-4d8e-9462-d0ba634198bb
8564 8u https://doi.org/10.1093/jncics/pky023

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