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Sökning: onr:"swepub:oai:lup.lub.lu.se:80bb845e-f1b6-44b1-a638-9f29bd748f27" > Occurrence of selen...

Occurrence of selenoprotein enzyme activities and mRNA in bovine mammary tissue.

Bruzelius, Katharina, (författare)
Lunds universitet, Lund University, Naturvetenskapliga fakulteten, Faculty of Science, Kemiska institutionen, Department of Chemistry, Centrum för tillämpade biovetenskaper, Center for Applied Life Sciences, Tillämpad biokemi, Pure and Applied Biochemistry
Hoac, Tien, (författare)
Lunds universitet, Lund University, Naturvetenskapliga fakulteten, Faculty of Science, Kemiska institutionen, Department of Chemistry, Centrum för tillämpade biovetenskaper, Center for Applied Life Sciences, Tillämpad biokemi, Pure and Applied Biochemistry
Sundler, Roger, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för experimentell medicinsk vetenskap, Department of Experimental Medical Science
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Önning, Gunilla, (författare)
Lunds universitet, Lund University, Naturvetenskapliga fakulteten, Faculty of Science, Kemiska institutionen, Department of Chemistry, Centrum för tillämpade biovetenskaper, Center for Applied Life Sciences, Tillämpad biokemi, Pure and Applied Biochemistry
Åkesson, Björn, (författare)
Lunds universitet, Lund University, Naturvetenskapliga fakulteten, Faculty of Science, Kemiska institutionen, Department of Chemistry, Centrum för tillämpade biovetenskaper, Center for Applied Life Sciences, Tillämpad biokemi, Pure and Applied Biochemistry
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Lunds universitet Tillämpad biokemi. (creator_code:org_t)
Lunds universitet Institutionen för experimentell medicinsk vetenskap. (creator_code:org_t)
2007
Engelska.
Ingår i: Journal of Dairy Science. - American Dairy Science Association. - 1525-3198. ; 90:2, s. 918-927
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • To elucidate the possible role of selenoproteins for milk formation and mammary gland physiology, the activities of selenoprotein enzymes and the expression of selenoprotein genes were studied in the bovine mammary gland. Messenger RNA was demonstrated for selenoprotein P, thioredoxin reductase 1, and for glutathione peroxidase (GPx) 1, 3, and 4. Significant differences in mRNA expression between the cows were seen for GPx 1 and GPx 3. The enzyme activity of glutathione peroxidase varied approximately 16-fold among cows, and the activity of thioredoxin reductase and the concentration of soluble Se varied approximately 6-fold among cows. There were positive correlations between glutathione peroxidase activity, thioredoxin reductase activity, and soluble Se, the correlation between glutathione peroxidase activity and soluble Se being the strongest. Furthermore, selenoprotein P expression correlated with GPx 1 mRNA expression and with soluble Se. There was also a correlation between glutathione peroxidase activity and the mRNA expression of GPx 1. The general conclusion from the data was that the activity of glutathione peroxidase and thioredoxin reductase and the mRNA expression of selenoprotein P and GPx 1 and 3 were influenced by Se status, but the expression of GPx 4 and thioredoxin reductase 1 were not. These results indicate that the Se status in mammary tissue is an important regulator of selenoprotein activity and expression, but that other factors are also in operation.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

Nyckelord

glutathione peroxidase
selenoprotein
mammary tissue
thioredoxin reductase

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Bruzelius, Katha ...
Hoac, Tien
Sundler, Roger
Önning, Gunilla
Åkesson, Björn
Om ämnet
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Medicinska grund ...
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Journal of Dairy ...
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Lunds universitet

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