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Drugs and Birth Defects: a knowledge database providing risk assessments based on national health registers

Nörby, Ulrika, (författare)
Stockholm County Council
Källén, Karin, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Lund, Department of Clinical Sciences, Lund, Sektion V, Division V, Obstetrik och gynekologi, Lund, Department of Obstetrics and Gynaecology (Lund), Tornbladinstitutet, Tornblad Institute
Eiermann, Birgit (författare)
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Korkmaz, Seher (författare)
Winbladh, Birger (författare)
Gustafsson, Lars L. (författare)
Norby, U (författare)
Kallen, K (författare)
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Lunds universitet Tornbladinstitutet. (creator_code:org_t)
Lunds universitet EpiHealth: Epidemiology for Health. (creator_code:org_t)
Ingår i: European Journal of Clinical Pharmacology. - Springer. - 1432-1041. ; 69:4, s. 889-899
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
  • To present concept, methods and use of a knowledge database providing assessments of potential fetal risks for all drugs on the Swedish market. Assessments of fetal risks are made primarily by analyzing prospective epidemiological data from the Swedish Medical Birth Register on drug intake in relation to birth outcome. This is complemented by evaluation of the scientific literature. Following standardized working procedures, a statement is compiled for each substance, which is also classified into one of three categories depending on the estimated risk level. The final documents include drug product names on the market, via linkage to a medicinal products register. The information is free and published on the website www.janusinfo.se. It can also be used as an integrated part of electronic health records. The database covers assessments of fetal risks for close to 1,250 medicinal drug substances on the Swedish market. Each year, 96,000 searches are made, which might be compared to the around 100,000 children born in Sweden yearly. Apart from the Swedish Physicians' Desk Reference (Fass), the database is the most commonly used resource among specialists within gynaecology and perinatal medicine for information on drugs during pregnancy. A non-commercial knowledge base with assessments of fetal risk of different drugs is valued by health care professionals and is used extensively in Sweden. Based on analyses of national health registers, the database provides unique information on teratogenic drug risks.


MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)


Teratogenic effects
Drug-induced abnormalities
perinatal effects
Health registers
Knowledge bases

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