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Variations in the p...
Variations in the practice of molecular radiotherapy and implementation of dosimetry : results from a European survey
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- Sjögreen Gleisner, Katarina (författare)
- Lund University,Lunds universitet,Nuclear Medicine Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund Univ, Dept Med Radiat Phys, Clin Sci Lund, Lund, Sweden.
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- Spezi, Emiliano (författare)
- Cardiff University,Cardiff Univ, Sch Engn, Cardiff, S Glam, Wales.
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- Solny, Pavel (författare)
- University Hospital Motol,Charles Univ Prague, Motol Univ Hosp, Dept Nucl Med & Endocrinol, Fac Med 2, Prague, Czech Republic.
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- Gabina, Pablo Minguez (författare)
- Gurutzeta/Cruces University Hospital,Gurutzeta Cruces Univ Hosp, Dept Med Phys & Radiat Protect, Baracaldo, Spain.
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- Cicone, Francesco (författare)
- Sapienza University of Rome,Sapienza Univ Rome, Dept Surg & Med Sci & Translat Med, St Andrea Hosp, Nucl Med, Rome, Italy.
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- Stokke, Caroline (författare)
- Oslo university hospital,Oslo Univ Hosp, Dept Diagnost Phys, Oslo, Norway.
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- Chiesa, Carlo (författare)
- Istituto Nazionale dei Tumori,Fdn IRCCS Ist Nazl Tumori, Div Nucl Med, Milan, Italy.
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- Paphiti, Maria (författare)
- Pammakaristos Hospital,Pammakaristos Hosp, Dept Med Phys, Athens, Greece.
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- Brans, Boudewijn (författare)
- Ghent University Hospital,Univ Hosp, Dept Nucl Med, Ghent, Belgium.;Univ Hosp, PET Ctr, Ghent, Belgium.
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- Sandström, Mattias (författare)
- Uppsala universitet,Radiologi
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- Tipping, Jill (författare)
- Christie NHS Foundation Trust,Christie NHS Fdn Trust, Nucl Med, Manchester, Lancs, England.
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- Konijnenberg, Mark (författare)
- Erasmus University Medical Center,Erasmus MC, Dept Nucl Med, Rotterdam, Netherlands.
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- Flux, Glenn (författare)
- Institute of Cancer Research London,Royal Marsden Hosp, Dept Phys, Sutton, Surrey, England.;Inst Canc Res, Sutton, Surrey, England.
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(creator_code:org_t)
- 2017-12-04
- 2017
- Engelska.
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Ingår i: EJNMMI Physics. - : Springer Science and Business Media LLC. - 2197-7364. ; 4:1
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Abstract
Ämnesord
Stäng
- Background: Currently, the implementation of dosimetry in molecular radiotherapy (MRT) is not well investigated, and in view of the Council Directive (2013/59/Euratom), there is a need to understand the current availability of dosimetry-based MRT in clinical practice and research studies. The aim of this study was to assess the current practice of MRT and dosimetry across European countries. Methods: An electronic questionnaire was distributed to European countries. This addressed 18 explicitly considered therapies, and for each therapy, a similar set of questions were included. Questions covered the number of patients and treatments during 2015, involvement of medical specialties and medical physicists, implementation of absorbed dose planning, post-therapy imaging and dosimetry, and the basis of therapy prescription. Results: Responses were obtained from 26 countries and 208 hospitals, administering in total 42,853 treatments. The most common therapies were 131I-NaI for benign thyroid diseases and thyroid ablation of adults. The involvement of a medical physicist (mean over all 18 therapies) was reported to be either minority or never by 32% of the responders. The percentage of responders that reported that dosimetry was included on an always/majority basis differed between the therapies and showed a median value of 36%. The highest percentages were obtained for 177Lu-PSMA therapy (100%), 90Y microspheres of glass (84%) and resin (82%), 131I-mIBG for neuroblastoma (59%), and 131I-NaI for benign thyroid diseases (54%). The majority of therapies were prescribed based on fixed-activity protocols. The highest number of absorbed-dose based prescriptions were reported for 90Y microsphere treatments in the liver (64% and 96% of responses for resin and glass, respectively), 131I-NaI treatment of benign thyroid diseases (38% of responses), and for 131I-mIBG treatment of neuroblastoma (18% of responses). Conclusions: There is a wide variation in MRT practice across Europe and for different therapies, including the extent of medical-physicist involvement and the implementation of dosimetry-guided treatments.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Nyckelord
- Dosimetry
- European survey
- Molecular radiotherapy
- Radionuclide therapy
- Radiopharmaceutical therapy
- Molecular radiotherapy
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Sjögreen Gleisne ...
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Spezi, Emiliano
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Solny, Pavel
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Gabina, Pablo Mi ...
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Cicone, Francesc ...
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Stokke, Caroline
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Chiesa, Carlo
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Paphiti, Maria
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Brans, Boudewijn
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Sandström, Matti ...
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Tipping, Jill
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Konijnenberg, Ma ...
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Flux, Glenn
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EJNMMI Physics
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Lunds universitet
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