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The hippocampus in families with schizophrenia in relation to obstetric complications

Ebner, Florian, (författare)
University of Bonn
Tepest, Ralf, (författare)
University of Cologne
Dani, Indra, (författare)
University of Bonn
visa fler...
Pfeiffer, Ute, (författare)
University of Bonn
Schulze, Thomas G., (författare)
Heidelberg University
Rietschel, Marcella, (författare)
Heidelberg University
Maier, Wolfgang, (författare)
University of Bonn
Träber, Frank, (författare)
University of Bonn
Block, Wolfgang, (författare)
University of Bonn
Schild, Hans H., (författare)
University of Bonn
Wagner, Michael, (författare)
University of Bonn
Steinmetz, Helmuth, (författare)
Goethe University, University of British Columbia
Gaebel, Wolfgang, (författare)
Heinrich Heine University Düsseldorf
Honer, William G., (författare)
University of British Columbia
Schneider-Axmann, Thomas, (författare)
University of Göttingen
Falkai, Peter, (författare)
University of Göttingen
visa färre...
2008
Engelska 8 s.
Ingår i: Schizophrenia Research. - Elsevier. - 0920-9964. ; 104:1-3, s. 71-78
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Hippocampal volume reduction is a well replicated finding in schizophrenia. Evidence indicates a contribution of genetic and environmental factors, especially the influence of obstetric complications to this volume reduction. The aim of this study was to compare hippocampal volume of schizophrenic patients as well as and their relatives with control subjects and to quantify the additional contribution of obstetric complications. Methods: T1 weighted MRI brain scans of 50 schizophrenic patients, 88 first-degree relatives and 53 healthy control subjects were used to perform volumetric measurements on the left and right hippocampus. A set of clinical measures including obstetric complications were recorded for all family members. Results: Numerically our measurements revealed a hippocampal volume reduction in schizophrenic patients (left: - 14%, right: - 15%) and, although less pronounced, in their unaffected relatives (left: - 6%, right: - 10%). Noted differences in hippocampal volume between schizophrenic patients and controls were only significant for the left side. Hippocampal volumes of patients and their relatives with obstetric complications were reduced bilaterally. Conclusions: Hippocampal volume reduction is present in schizophrenic patients and their first-degree relatives, suggesting an influence of genetic factors.. In addition, however, obstetric complications have also been shown to play a major role.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

Family study
Hippocampus
MRI
Obstetric complications
Schizophrenia

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