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Sökning: onr:"swepub:oai:lup.lub.lu.se:915b18b2-fe38-40b5-800a-db430d065837" > Influence of Polymo...

Influence of Polymorphisms in the RANKL/RANK/OPG Signaling Pathway on Volumetric Bone Mineral Density and Bone Geometry at the Forearm in Men

Roshandel, Delnaz (författare)
Holliday, Kate L. (författare)
Pye, Stephen R. (författare)
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Ward, Kate A. (författare)
Boonen, Steven (författare)
Vanderschueren, Dirk (författare)
Borghs, Herman (författare)
Huhtaniemi, Ilpo T. (författare)
Adams, Judith E. (författare)
Bartfai, Gyorgy (författare)
Casanueva, Felipe F. (författare)
Finn, Joseph D. (författare)
Forti, Gianni (författare)
Giwercman, Aleksander, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Reproduktionsmedicin, Malmö, Reproductive medicine, Malmö
Han, Thang S. (författare)
Kula, Krzysztof (författare)
Lean, Michael E. (författare)
Pendleton, Neil (författare)
Punab, Margus (författare)
Silman, Alan J. (författare)
Wu, Frederick C. (författare)
Thomson, Wendy (författare)
O'Neill, Terence W. (författare)
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2011
Engelska.
Ingår i: Calcified Tissue International. - Springer. - 1432-0827. ; 89:6, s. 446-455
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • We sought to determine the influence of single-nucleotide polymorphisms (SNPs) in RANKL, RANK, and OPG on volumetric bone mineral density (vBMD) and bone geometry at the radius in men. Pairwise tag SNPs (r (2) a parts per thousand yen 0.8) for RANKL (n = 8), RANK (n = 44), and OPG (n = 22) and five SNPs near RANKL and OPG strongly associated with areal BMD in genomewide association studies were previously genotyped in men aged 40-79 years in the European Male Ageing Study (EMAS). Here, these SNPs were analyzed in a subsample of men (n = 589) who had peripheral quantitative computed tomography (pQCT) performed at the distal (4%) and mid-shaft (50%) radius. Estimated parameters were total and trabecular vBMD (mg/mm(3)) and cross-sectional area (mm(2)) at the 4% site and cortical vBMD (mg/mm(3)); total, cortical, and medullary area (mm(2)); cortical thickness (mm); and stress strain index (SSI) (mm(3)) at the 50% site. We identified 12 OPG SNPs associated with vBMD and/or geometric parameters, including rs10505348 associated with total vBMD (beta [95% CI] = 9.35 [2.12-16.58], P = 0.011), cortical vBMD (beta [95% CI] = 5.62 [2.10-9.14], P = 0.002), cortical thickness (beta [95% CI] = 0.08 [0.03-0.13], P = 0.002), and medullary area (beta [95% CI] = -2.90 [-4.94 to -0.86], P = 0.005) and rs2073618 associated with cortical vBMD (beta [95% CI] = -4.30 [-7.78 to -0.82], P = 0.015) and cortical thickness (beta [95% CI] = -0.08 [-0.13 to -0.03], P = 0.001). Three RANK SNPs were associated with vBMD, including rs12956925 associated with trabecular vBMD (beta [95% CI] = -7.58 [-14.01 to -1.15], P = 0.021). There were five RANK SNPs associated with geometric parameters, including rs8083511 associated with distal radius cross-sectional area (beta [95% CI] = 8.90 [0.92-16.88], P = 0.029). No significant association was observed between RANKL SNPs and pQCT parameters. Our findings suggest that genetic variation in OPG and RANK influences radius vBMD and geometry in men.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynecology and Reproductive Medicine (hsv//eng)

Nyckelord

Osteoporosis
Genetic association
Genetic polymorphism
Male
QCT

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