Centre for Research in Environmental Epidemiology (CREAL)
Stephanou, Euripides G. (författare)
University of Crete
Myridakis, Antonis (författare)
University of Crete
Fazzo, Lucia (författare)
Istituto Superiore di Sanità
De Santis, Marco (författare)
Istituto Superiore di Sanità
Comba, Pietro (författare)
Istituto Superiore di Sanità
Kiviranta, Hannu (författare)
Finnish National Institute for Health and Welfare
Rantakokko, Panu (författare)
Finnish National Institute for Health and Welfare
Airaksinen, Riikka (författare)
Finnish National Institute for Health and Welfare
Ruokojarvi, Paivi (författare)
Finnish National Institute for Health and Welfare
Gilthorpe, Mark (författare)
University of Leeds
Fleming, Sarah (författare)
University of Leeds
Fleming, Thomas (författare)
University of Leeds
Tu, Yu Kang (författare)
University of Leeds
Jönsson, Bo A(författare)
Lundh, Thomas (författare)
Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups
Chen, Wei-Jung (författare)
National Taiwan University
Lee, Wen Chung (författare)
National Taiwan University
Hsiao, Chuhsing Kate (författare)
National Taiwan University
Chien, Kuo Liong (författare)
National Taiwan University
Kuo, Po Hsiu (författare)
National Taiwan University
Hung, Hung (författare)
National Taiwan University
Liao, Shu Fen (författare)
National Taiwan University
Hebels, Dennie G(författare)
Siskos, Alexandros P(författare)
Bergdahl, Ingvar A (författare)
Umeå universitet,Yrkes- och miljömedicin,Enheten för biobanksforskning
We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 (haem oxygenase 1) and BCL2L1 (BCL2-like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment.
Ämnesord
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Beroendelära (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Substance Abuse (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)