SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:lup.lub.lu.se:9215acb0-69f2-4bbf-be05-7f4b9bf1794f"
 

Sökning: onr:"swepub:oai:lup.lub.lu.se:9215acb0-69f2-4bbf-be05-7f4b9bf1794f" > Genome-wide meta-an...

Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain

Suri, Pradeep, (författare)
U.S. Department of Veterans Affairs, VA Puget Sound Health Care System, University of Washington
Palmer, Melody R., (författare)
University of Washington
Tsepilov, Yakov A., (författare)
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk State University
visa fler...
Freidin, Maxim B., (författare)
King's College London
Boer, Cindy G., (författare)
Erasmus University Medical Center
Yau, Michelle S., (författare)
Beth Israel Deaconess Medical Center, Harvard University, Hebrew SeniorLife
Evans, Daniel S., (författare)
California Pacific Medical Center
Gelemanovic, Andrea, (författare)
University of Split
Bartz, Traci M., (författare)
University of Washington
Nethander, Maria, (författare)
University of Gothenburg
Arbeeva, Liubov, (författare)
University of North Carolina
Karssen, Lennart, (författare)
PolyOmica
Neogi, Tuhina, (författare)
Boston University
Campbell, Archie, (författare)
University of Edinburgh
Mellstrom, Dan, (författare)
University of Gothenburg
Ohlsson, Claes, (författare)
University of Gothenburg
Marshall, Lynn M., (författare)
Oregon Health & Science University
Orwoll, Eric, (författare)
Oregon Health & Science University
Uitterlinden, Andre, (författare)
Erasmus University Medical Center
Rotter, Jerome I., (författare)
Harbor–UCLA Medical Center, University of California, Los Angeles
Lauc, Gordan, (författare)
Genos d.o.o, University of Zagreb
Psaty, Bruce M., (författare)
Kaiser Permanente Research Institute, University of Washington
Karlsson, Magnus K., (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Malmö, Department of Clinical Sciences, Malmö, Skåne University Hospital
Lane, Nancy E., (författare)
University of California, Davis
Jarvik, Gail P., (författare)
University of Washington
Polasek, Ozren, (författare)
University of Split, Psychiatric Hospital "Sveti Ivan"
Hochberg, Marc, (författare)
University of Maryland, Baltimore
Jordan, Joanne M., (författare)
University of North Carolina
Van Meurs, Joyce B.J., (författare)
Erasmus University Medical Center
Jackson, Rebecca, (författare)
Ohio State University
Nielson, Carrie M., (författare)
Oregon Health & Science University
Mitchell, Braxton D., (författare)
University of Maryland, Baltimore, Veterans Health Administration
Smith, Blair H., (författare)
University of Dundee
Hayward, Caroline, (författare)
University of Edinburgh
Smith, Nicholas L., (författare)
University of Washington, Kaiser Permanente Research Institute, U.S. Department of Veterans Affairs
Aulchenko, Yurii S., (författare)
PolyOmica
Williams, Frances M.K., (författare)
King's College London
Campbel, A. (författare)
Mellström, Dan, 1945- (författare)
Göteborgs universitet, Centre for Bone and Arthritis Research, Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition, Gothenburg University, Centre for Bone and Arthritis Research, Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
visa färre...
Göteborgs universitet Sahlgrenska akademin. Centre for Bone and Arthritis Research. 
Göteborgs universitet Sahlgrenska akademin. Core Facilities, Bioinformatics. 
visa fler...
Göteborgs universitet Sahlgrenska akademin. Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition. 
visa färre...
2018
Engelska.
Ingår i: PLoS Genetics. - Public Library of Science. - 1553-7390. ; 14:9
Läs hela texten (fulltext)
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Back pain is the #1 cause of years lived with disability worldwide, yet surprisingly little is known regarding the biology underlying this symptom. We conducted a genome-wide association study (GWAS) meta-analysis of chronic back pain (CBP). Adults of European ancestry were included from 15 cohorts in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and from the UK Biobank interim data release. CBP cases were defined as those reporting back pain present for ≥3–6 months; non-cases were included as comparisons (“controls”). Each cohort conducted genotyping using commercially available arrays followed by imputation. GWAS used logistic regression models with additive genetic effects, adjusting for age, sex, study-specific covariates, and population substructure. The threshold for genome-wide significance in the fixed-effect inverse-variance weighted meta-analysis was p<5×10−8. Suggestive (p<5×10−7) and genome-wide significant (p<5×10−8) variants were carried forward for replication or further investigation in the remaining UK Biobank participants not included in the discovery sample. The discovery sample comprised 158,025 individuals, including 29,531 CBP cases. A genome-wide significant association was found for the intronic variant rs12310519 in SOX5 (OR 1.08, p = 7.2×10−10). This was subsequently replicated in 283,752 UK Biobank participants not included in the discovery sample, including 50,915 cases (OR 1.06, p = 5.3×10−11), and exceeded genome-wide significance in joint meta-analysis (OR 1.07, p = 4.5×10−19). We found suggestive associations at three other loci in the discovery sample, two of which exceeded genome-wide significance in joint meta-analysis: an intergenic variant, rs7833174, located between CCDC26 and GSDMC (OR 1.05, p = 4.4×10−13), and an intronic variant, rs4384683, in DCC (OR 0.97, p = 2.4×10−10). In this first reported meta-analysis of GWAS for CBP, we identified and replicated a genetic locus associated with CBP (SOX5). We also identified 2 other loci that reached genome-wide significance in a 2-stage joint meta-analysis (CCDC26/GSDMC and DCC).

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Ortopedi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Orthopedics (hsv//eng)

Nyckelord

ld score regression
body-mass index
genetic-variants
intervertebral
disc
knee osteoarthritis
cotwin control
risk-factors
heritability
netrin-1
traits
Genetics & Heredity

Publikations- och innehållstyp

art (ämneskategori)
ref (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy