SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:lup.lub.lu.se:929afbb3-ee6c-4b15-955e-7c86f67b4bde"
 

Sökning: onr:"swepub:oai:lup.lub.lu.se:929afbb3-ee6c-4b15-955e-7c86f67b4bde" > Real-world effectiv...

Real-world effectiveness of osteoporosis treatment in the oldest old

Ström, O. (författare)
Karolinska Institutet,Karolinska Inst, Stockholm, Sweden; Quantify Res, Stockholm, Sweden
Lauppe, R. (författare)
Quantify Research AB,Quantify Res, Sweden,Quantify Res, Stockholm, Sweden
Spångéus, A. (författare)
Linköping University Hospital,Linköping Univ, Linköping Univ Hosp, Linköping, Sweden
visa fler...
Ortsäter, G. (författare)
Quantify Research AB,Quantify Res, Stockholm, Sweden
O’Kelly, J. (författare)
Amgen Ltd.
Åkesson, K. (författare)
Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skåne Univ Hosp, Malmö, Sweden
Ortsater, G (författare)
Akesson, K (författare)
O'Kelly, J (författare)
Lauppe, R (författare)
Strom, O (författare)
Karolinska Institutet
Ljunggren, O (författare)
Sphangeus, A (författare)
Akesson, K. (författare)
Lund Univ, Sweden
Strom, O. (författare)
Karolinska Inst, Sweden; Quantify Res, Sweden
Ortsater, G. (författare)
Quantify Res, Sweden
Ljunggren, O. (författare)
Uppsala Univ, Sweden
Spångeus, Anna (författare)
Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken
OKelly, J. (författare)
Amgen Ltd, England
O'Kelly, J. (författare)
Amgen Ltd, Uxbridge, Middx, England
Ljunggren, Östen (författare)
Uppsala universitet,Endokrinologi och mineralmetabolism
visa färre...
 (creator_code:org_t)
Springer, 2020-03-30
Engelska.
Ingår i: Osteoporosis International. - : Springer. - 0937-941X .- 1433-2965. ; 31:8, s. 1525-1533
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Summary: We studied effectiveness of osteoporosis treatment in women older than 80 years, who often are not included in clinical trials. Treatments were as effective on bone density and fractures as in younger women. Introduction: To study real-world effectiveness of osteoporosis treatment on BMD and fractures in the oldest old women (≥ 80 years) compared with women (60–79 years) in the clinical setting using Swedish health register data. Methods: National registers and data from DXA machines were used to study effectiveness of all available osteoporosis treatments in women 60–79 and ≥ 80 years using three approaches: (1) Total Hip BMD change up to 8 years after treatment start; (2) fracture incidence where patients served as their own controls, comparing the first 3 months after treatment start with the subsequent 12 months; and (3) comparison of fracture incidence post-fracture in women ≥ 80 years treated with osteoporosis treatment or calcium/vitamin D. Results: Analysis 1: Total Hip BMD increased by up to 6.7% and 7.7% in women 60–79 and ≥ 80 years old, respectively. The mean increase in BMD was 1.1%-units per year in both age groups. Analysis 2: Relative to the 3-month baseline, fracture incidence decreased during the subsequent 12 months of treatment. Incidence rate ratios were estimated at 0.65, 0.74, 0.29, and 0.81 for any, hip, vertebral, and non-hip-non-vertebral fracture, respectively. Analysis 3: A 24-month incidence of any fracture in women ≥ 80 years given post-fracture osteoporosis treatment was lower (HR = 0.78) than in women given calcium/vitamin D, but treatment allocation was not random, with lower mortality (HR = 0.51) in patients receiving OP treatment. Conclusions: Osteoporosis medication in women > 80 years in clinical practice likely works, and the magnitude of effect is similar to what was estimated in younger women. The choice between osteoporosis treatment and calcium/vitamin D after fracture in women ≥ 80 years is not random but appears associated with the patient’s health status and presence of vertebral fractures, rather than the known risk profile of sustaining a fracture at a high age.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Ortopedi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Orthopedics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Allmänmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Family Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Orthopaedics (hsv//eng)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)

Nyckelord

Bisphosphonates
Bone mineral density
Elderly
Register
Retrospective
Women
Bisphosphonates; Bone mineral density; Elderly; Retrospective; Register; Women

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy