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Sökning: onr:"swepub:oai:lup.lub.lu.se:93755d20-1855-4593-8256-dd897f5512d8" > Search for multiple...

Search for multiple myeloma risk factors using Mendelian randomization

Went, Molly (författare)
Institute of Cancer Research London
Cornish, Alex J. (författare)
Institute of Cancer Research London
Law, Philip J. (författare)
Institute of Cancer Research London
visa fler...
Kinnersley, Ben (författare)
Institute of Cancer Research London
van Duin, Mark (författare)
Erasmus University Medical Center
Weinhold, Niels (författare)
Heidelberg University
Försti, Asta (författare)
German Cancer Research Centre
Hansson, Markus (författare)
Lund University,Lunds universitet,Myelomgruppen,Forskargrupper vid Lunds universitet,LUCC - Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Myeloma research group,Lund University Research Groups,LUCC - Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
Sonneveld, Pieter (författare)
Erasmus University Medical Center
Goldschmidt, Hartmut (författare)
Heidelberg University,National Centre of Tumor Diseases
Morgan, Gareth J. (författare)
NYU Langone
Hemminki, Kari (författare)
German Cancer Research Centre,Charles University in Prague
Nilsson, Björn (författare)
Lund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,LUCC - Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC - Lund University Cancer Centre,Other Strong Research Environments,Broad Institute
Kaiser, Martin (författare)
Institute of Cancer Research London
Houlston, Richard S. (författare)
Institute of Cancer Research London
visa färre...
 (creator_code:org_t)
American Society of Hematology, 2020
2020
Engelska 8 s.
Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529. ; 4:10, s. 2172-2179
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The etiology of multiple myeloma (MM) is poorly understood. Summary data from genome-wide association studies (GWASs) of multiple phenotypes can be exploited in a Mendelian randomization (MR) phenome-wide association study (PheWAS) to search for factors influencing MM risk. We performed an MR-PheWAS analyzing 249 phenotypes, proxied by 10 225 genetic variants, and summary genetic data from a GWAS of 7717 MM cases and 29 304 controls. Odds ratios (ORs) per 1 standard deviation increase in each phenotype were estimated under an inverse variance weighted random effects model. A Bonferroni-corrected threshold of P 5 2 3 1024 was considered significant, whereas P,.05 was considered suggestive of an association. Although no significant associations with MM risk were observed among the 249 phenotypes, 28 phenotypes showed evidence suggestive of association, including increased levels of serum vitamin B6 and blood carnitine (P 5 1.1 3 1023) with greater MM risk and v-3 fatty acids (P 5 5.4 3 1024) with reduced MM risk. A suggestive association between increased telomere length and reduced MM risk was also noted; however, this association was primarily driven by the previously identified risk variant rs10936599 at 3q26 (TERC). Although not statistically significant, increased body mass index was associated with increased risk (OR, 1.10; 95% confidence interval, 0.99-1.22), supporting findings from a previous meta-analysis of prospective observational studies. Our study did not provide evidence supporting any modifiable factors examined as having a major influence on MM risk; however, it provides insight into factors for which the evidence has previously been mixed.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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