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Bone Scan Index as ...
Bone Scan Index as an Imaging Biomarker in Metastatic Castration-resistant Prostate Cancer : A Multicentre Study Based on Patients Treated with Abiraterone Acetate (Zytiga) in Clinical Practice
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- Reza Felix, Mariana (författare)
- Lund University,Lunds universitet,Nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Nuclear medicine, Malmö,Lund University Research Groups,Skåne University Hospital
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- Ohlsson, Mattias (författare)
- Lund University,Lunds universitet,Institutionen för astronomi och teoretisk fysik - Har omorganiserats,Naturvetenskapliga fakulteten,Department of Astronomy and Theoretical Physics - Has been reorganised,Faculty of Science
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- Kaboteh, Reza (författare)
- Sahlgrenska University Hospital
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- Anand, Aseem (författare)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups
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- Franck Lissbrant, Ingela, 1969 (författare)
- Sahlgrenska University Hospital
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- Damber, Jan-Erik, 1949 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
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- Widmark, Anders (författare)
- Norrland University Hospital
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- Thellenberg-Karlsson, Camilla, 1972- (författare)
- Umeå universitet,Umeå University,Institutionen för strålningsvetenskaper
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- Budäus, Lars (författare)
- University Medical Center Hamburg-Eppendorf
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- Steuber, Thomas (författare)
- University Medical Center Hamburg-Eppendorf
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- Eichenauer, Till (författare)
- University Medical Center Hamburg-Eppendorf
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- Wollmer, Per (författare)
- Skåne University Hospital
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- Edenbrandt, Lars (författare)
- Sahlgrenska University Hospital,Skåne University Hospital
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- Trägårdh, Elin (författare)
- Skåne University Hospital
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- Bjartell, Anders (författare)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska 7 s.
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Ingår i: European Urology Focus. - : Elsevier BV. - 2405-4569. ; 2:5, s. 540-546
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Background Abiraterone acetate (AA) prolongs survival in metastatic castration-resistant prostate cancer (mCRPC) patients. To measure treatment response accurately in bone, quantitative methods are needed. The Bone Scan Index (BSI), a prognostic imaging biomarker, reflects the tumour burden in bone as a percentage of the total skeletal mass calculated from bone scintigraphy. Objective To evaluate the value of BSI as a biomarker for outcome evaluation in mCRPC patients on treatment with AA according to clinical routine. Design, setting, and participants We retrospectively studied 104 mCRPC patients who received AA following disease progression after chemotherapy. All patients underwent whole-body bone scintigraphy before and during AA treatment. Baseline and follow-up BSI data were obtained using EXINI BoneBSI software (EXINI Diagnostics AB, Lund, Sweden). Outcome measurements and statistical analysis Associations between change in BSI, clinical parameters at follow-up, and overall survival (OS) were evaluated using the Cox proportional hazards regression models and Kaplan-Meier estimates. Discrimination between variables was assessed using the concordance index (C-index). Results and limitations Patients with an increase in BSI at follow-up of at most 0.30 (n = 54) had a significantly longer median survival time than those with an increase of BSI >0.30 (n = 50) (median: 16 vs 10 mo; p = 0.001). BSI change was also associated with OS in a multivariate Cox analysis including commonly used clinical parameters for prognosis (C-index = 0.7; hazard ratio: 1.1; p = 0.03). The retrospective design was a limitation. Conclusions Change in BSI was significantly associated with OS in mCRPC patients undergoing AA treatment following disease progression in a postchemotherapy setting. BSI may be a useful imaging biomarker for outcome evaluation in this group of patients, and it could be a valuable complementary tool in monitoring patients with mCRPC on second-line therapies. Patient summary Bone Scan Index (BSI) change is related to survival time in metastatic castration-resistant prostate cancer (mCRPC) patients on abiraterone acetate. BSI may be a valuable complementary decision-making tool supporting physicians monitoring patients with mCRPC on second-line therapies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Abiraterone acetate
- Bone metastasis
- Bone Scan Index
- Castration-resistant prostate cancer
- Abiraterone acetate
- Abiraterone acetateCastration-resistant prostate cancerBone metastasisBone Scan Index
Publikations- och innehållstyp
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Reza Felix, Mari ...
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Ohlsson, Mattias
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Kaboteh, Reza
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Anand, Aseem
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Franck Lissbrant ...
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Damber, Jan-Erik ...
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Widmark, Anders
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Thellenberg-Karl ...
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Budäus, Lars
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Steuber, Thomas
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Eichenauer, Till
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Wollmer, Per
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Edenbrandt, Lars
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Trägårdh, Elin
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Bjartell, Anders
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
- Artiklar i publikationen
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European Urology ...
- Av lärosätet
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Lunds universitet
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Umeå universitet
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Göteborgs universitet