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Sökning: onr:"swepub:oai:lup.lub.lu.se:9cb6051a-14e7-41df-bdb0-5aa3c9e87265" > A comprehensive met...

A comprehensive meta-analysis of case-control association studies to evaluate polymorphisms associated with the risk of differentiated thyroid carcinoma

Figlioli, Gisella, (författare)
University of Pisa
Elisei, Rossella, (författare)
University of Pisa
Romei, Cristina, (författare)
University of Pisa
visa fler...
Melaiu, Ombretta, (författare)
University of Pisa
Cipollini, Monica, (författare)
University of Pisa
Bambi, Franco, (författare)
Meyer Children's Hospital
Chen, Bowang, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Malmö, Department of Clinical Sciences, Malmö, Genetisk och molekylär epidemiologi, Genetic and Molecular Epidemiology, German Cancer Research Centre
Kohler, Aleksandra, (författare)
St.Agnes-Hospital Bocholt
Cristaudo, Alfonso, (författare)
University of Pisa
Hemminki, Kari, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Malmö, Department of Clinical Sciences, Malmö, Genetisk och molekylär epidemiologi, Genetic and Molecular Epidemiology, German Cancer Research Centre, Center for Primary Health Care Research
Gemignani, Federica, (författare)
University of Pisa
Forsti, Asta, (författare)
German Cancer Research Centre
Landi, Stefano, (författare)
University of Pisa
visa färre...
Lunds universitet Genetisk och molekylär epidemiologi. (creator_code:org_t)
Lunds universitet EpiHealth: Epidemiology for Health. (creator_code:org_t)
2016
Engelska 14 s.
Ingår i: Cancer Epidemiology Biomarkers & Prevention. - American Association for Cancer Research. - 1055-9965. ; 25:4, s. 700-713
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Linkage analyses and association studies suggested that inherited genetic variations play a role in the development of differentiated thyroid carcinoma (DTC). Methods: We combined the results from a genome-wide association study (GWAS) performed by our group and frompublished studies onDTC. With a first approach, we evaluated whether a SNP published as associated with the risk of DTC could replicate in our GWAS (using FDR as adjustment for multiple comparisons). With the second approach, meta-analyses were performed between literature and GWAS when both sources suggested an association, increasing the statistical power of the analysis. Results: rs1799814 (CYP1A1), rs1121980 (FTO), and 3 SNPs within 9q22 (rs965513, rs7048394, and rs894673) replicated the associations described in the literature. In addition, the meta-analyses between literature and GWAS revealed 10 more SNPs within 9q22, six within FTO, two within SOD1, and single variations within HUS1, WDR3, UGT2B7, ALOX12, TICAM1, ATG16L1, HDAC4, PIK3CA, SULF1, IL11RA, VEGFA, and 1p31.3, 2q35, 8p12, and 14q13. Conclusion: This analysis confirmed several published risk loci that could be involved in DTC predisposition. Impact: These findings provide evidence for the role of germline variants in DTC etiology and are consistent with a polygenic model of the disease.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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