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Sökning: onr:"swepub:oai:lup.lub.lu.se:a1eaf076-050a-40f6-bf06-b2313279f554" > Analysis of the dis...

Analysis of the distribution and frequency of trisomy 7 in vivo in synovia from patients with osteoarthritis and pigmented villonodular synovitis

Dahlén, A, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för laboratoriemedicin, Department of Laboratory Medicine, Avdelningen för klinisk genetik, Division of Clinical Genetics
Broberg, K, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för laboratoriemedicin, Department of Laboratory Medicine, Avdelningen för klinisk genetik, Division of Clinical Genetics
Domanski, H A, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Lund, Department of Clinical Sciences, Lund, Tumörmikromiljö, Tumor microenvironment, Sektion I, Section I
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Toksvig-Larsen, S, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Lund, Department of Clinical Sciences, Lund, Sektion III, Section III, Ortopedi, Lund, Orthopaedics (Lund)
Lindstrand, A, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Lund, Department of Clinical Sciences, Lund, Sektion III, Section III, Ortopedi, Lund, Orthopaedics (Lund)
Mandahl, N, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för laboratoriemedicin, Department of Laboratory Medicine, Avdelningen för klinisk genetik, Division of Clinical Genetics
Mertens, F, (författare)
Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för laboratoriemedicin, Department of Laboratory Medicine, Avdelningen för klinisk genetik, Division of Clinical Genetics
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2001
Engelska 6 s.
Ingår i: Cancer Genetics and Cytogenetics. - Elsevier. - 0165-4608. ; 131:1, s. 19-24
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Osteoarthritis (OA) and pigmented villonodular synovitis (PVNS) are disorders associated with trisomy 7. The aim of the present study was to determine the frequency and distribution of the cells with +7 in vivo by analyzing sections of paraffin-embedded synovia from patients affected by OA, PVNS, other forms of synovitis [hemorragic synovitis (HS) and chronic synovitis (CS)], and from individuals without joint disease. Fluorescence in situ hybridization (FISH), using a centromeric probe for chromosome 7, showed that the mean frequency of trisomic nuclei in 5-microm sections was highest in PVNS (9.0%), followed by CS (5.9%), OA (5.6%), and HS (4.6%), whereas trisomic nuclei were rare (0.7%) in normal tissue. When 8-microm sections were studied, the frequencies of trisomic cells in OA and control synovia increased to 6.7% and 1.5%, respectively. Trisomic nuclei were found in all cases, including those for which cytogenetic analysis of short-term cultures had not disclosed any trisomic cells. Overall, the trisomic cells were scattered within the tissue. However, small clusters of cells with +7 were found in three cases. By hematoxylin-eosin staining of the slides used for FISH analysis it could be shown that the clustered trisomic cells were proliferating synoviocytes within villous extensions of the synovial membrane.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskaper -- Miljömedicin och yrkesmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Environmental Health and Occupational Health (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Ortopedi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Orthopedics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Nyckelord

Adult
Aged
Aged, 80 and over
Cell Count
Chromosomes, Human, Pair 7
Data Interpretation, Statistical
Female
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Male
Middle Aged
Osteoarthritis
Synovial Fluid
Synovitis, Pigmented Villonodular
Trisomy
Journal Article
Research Support, Non-U.S. Gov't

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