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Sökning: onr:"swepub:oai:lup.lub.lu.se:a2da45a7-23fa-45a9-ac0c-a9db2564fa30" > Androgen receptor p...

Androgen receptor polymorphism dependent variation in prostate specific antigen concentrations of European men.

Bentmar Holgersson, Magdalena, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Molekylärgenetisk reproduktionsmedicin, Malmö, Molecular genetic reproductive medicine, Malmö
Giwercman, Aleksander, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Reproduktionsmedicin, Malmö, Reproductive medicine, Malmö
Bjartell, Anders, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Urologisk cancerforskning, Malmö, Urological cancer, Malmö
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Wu, Frederick C W (författare)
Huhtaniemi, Ilpo T (författare)
O'Neill, Terence W (författare)
Pendleton, Neil (författare)
Vanderschueren, Dirk (författare)
Lean, Michael E J (författare)
Han, Thang S (författare)
Finn, Joseph D (författare)
Kula, Krzysztof (författare)
Forti, Gianni (författare)
Casanueva, Felipe F (författare)
Bartfai, György (författare)
Punab, Margus (författare)
Giwercman, Yvonne, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Molekylärgenetisk reproduktionsmedicin, Malmö, Molecular genetic reproductive medicine, Malmö, Reproduktionsmedicin, Malmö, Reproductive medicine, Malmö
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2014
Engelska.
Ingår i: Cancer Epidemiology Biomarkers & Prevention. - American Association for Cancer Research. - 1538-7755. ; 23:10, s. 2048-2056
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background Androgens acting via the androgen receptor (AR) stimulate production of prostate specific antigen (PSA), which is a clinical marker of prostate cancer (PCa). Since genetic variants in the AR may have a significant impact on the risk of being diagnosed with PCa, the aim was to investigate if AR-variants were associated with the risk of having PSA above clinically used cut-off thresholds of 3 or 4 ng/mL in men without PCa. Methods Men without PCa history (n=1744) were selected from the European Male Ageing Study (EMAS) cohort of 40-80 year old men from 8 different European centers. Using linear and logistic regression models, with age and center as covariates, we investigated whether AR-variants (CAG repeat-length and/or SNP genotype) were associated with having serum PSA concentrations above 3 or 4 ng/mL, which often are set as cut-off concentrations for further investigation of PCa. Results Carriers of the SNP rs1204038 A-allele (16% of the men) were more likely to have PSA>3 and 4 ng/mL (OR; 95%CI 1.65; 1.13-2.40 and 1.87; 1.18-2.96, respectively) than G-allele carriers. They also had shorter CAG-repeats (median 20 vs. 23, p<0.0005), but CAG repeat length per se did not affect the PSA concentrations. Conclusion The A-allele of the SNP rs1204038 gives a 65% higher risk of having PSA above 3 ng/mL than the G-allele in men without PCa, and thereby an increased risk of being referred for further examination on suspicion of PCa. Impact Serum PSA as a clinical marker could be improved by adjustment for AR-genotype.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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