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Sökning: onr:"swepub:oai:lup.lub.lu.se:ac8ee3fe-2b5b-44f7-8551-b733a7984dd7" > Circulating lipids,...

Circulating lipids, mammographic density, and risk of breast cancer in the Nurses’ Health Study and Nurses’ Health Study II

Lucht, Sarah A., (författare)
Heinrich Heine University Düsseldorf
Eliassen, A. Heather, (författare)
Brigham and Women's Hospital / Harvard Medical School, Harvard University
Bertrand, Kimberly A., (författare)
Boston University
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Ahern, Thomas P., (författare)
University of Vermont
Borgquist, Signe, (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, Lunds universitet, Lund University, Bröstcancer - prevention & intervention, Breast cancer prevention & intervention, Strategiska forskningsområden, Strategic Research Areas, BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation, BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation, Starka forskningsmiljöer, Strong Research Environments
Rosner, Bernard, (författare)
Harvard University
Hankinson, Susan E., (författare)
University of Massachusetts, Harvard University
Tamimi, Rulla M., (författare)
Brigham and Women's Hospital / Harvard Medical School, Harvard University
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Lunds universitet Bröstcancer - prevention & intervention. (creator_code:org_t)
Lunds universitet BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation. (creator_code:org_t)
2019
Engelska.
Ingår i: Cancer Causes and Control. - Springer. - 0957-5243. ; 30:9, s. 943-953
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Purpose: Epidemiologic evidence supports an association between high mammographic density and increased breast cancer risk yet etiologic mechanisms remain largely unknown. Mixed evidence exists as to whether circulating lipid levels influence mammographic density and breast cancer risk. Therefore, we examined these associations in the Nurses’ Health Study (NHS) and Nurses’ Health Study II (NHSII), two large prospective cohorts with information on PMD and circulating lipid measures, long follow-up, and breast cancer risk factor and outcome data. Methods: We conducted a nested case–control study among women in the NHS and NHSII. Percent mammographic density (PMD) was measured using Cumulus software, a computer-assisted method, on digitized film mammograms. Cross-sectional associations between circulating lipids [total cholesterol (n = 1,502), high-density lipoprotein (HDL-C; n = 579), and triglycerides (n = 655)] and PMD were evaluated among controls. All analyses were stratified by menopausal status at time of mammogram. Relative risks for breast cancer by lipid and PMD measures were estimated among postmenopausal women in the full nested case–control study (cases/controls for cholesterol, HDL-C, and triglycerides were 937/975, 416/449, and 506/537, respectively). Results: There were no significant associations between circulating lipid levels and PMD among healthy women, irrespective of menopausal status. The association between PMD and breast cancer risk among postmenopausal women was not modified by circulating lipid levels (p interaction = 0.83, 0.80, and 0.34 for total cholesterol, HDL-C, and triglycerides, respectively). Conclusion: Overall, no association was observed between lipid levels and PMD, and there was no evidence that lipid levels modified the association between PMD and breast cancer risk.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Breast density
Breast neoplasms
Cholesterol
Lipids
Mammography

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