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Sökning: onr:"swepub:oai:lup.lub.lu.se:aef9c0a2-c15b-4a78-a024-da868313faba" > Plasma fatty acid b...

Plasma fatty acid binding protein 4 and risk of sudden cardiac death in older adults

Djoussé, Luc, (författare)
Brigham and Women's Hospital / Harvard Medical School, Veterans Health Administration
Maziarz, Marlena, (författare)
University of Washington
Biggs, Mary L., (författare)
University of Washington
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Ix, Joachim H., (författare)
University of California, San Diego, VA San Diego Healthcare System
Zieman, Susan J., (författare)
National Institute on Aging, United States
Kizer, Jorge R., (författare)
Yeshiva University
Lemaitre, Rozenn N., (författare)
University of Washington
Mozaffarian, Dariush, (författare)
Brigham and Women's Hospital / Harvard Medical School
Tracy, Russell P., (författare)
University of Vermont
Mukamal, Kenneth J., (författare)
Harvard Medical School
Siscovick, David S., (författare)
University of Washington
Sotoodehnia, Nona, (författare)
University of Washington
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2013
Engelska.
Ingår i: Cardiology Research and Practice. - Hindawi Publishing Corporation. - 2090-8016. ; 1:1
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  • Although fatty acid binding protein 4 (FABP4) may increase risk of diabetes and exert negative cardiac inotropy, it is unknown whether plasma concentrations of FABP4 are associated with incidence of sudden cardiac death (SCD). We prospectively analyzed data on 4,560 participants of the Cardiovascular Health Study. FABP4 was measured at baseline using ELISA, and SCD events were adjudicated through review of medical records. We used Cox proportional hazards to estimate effect measures. During a median followup of 11.8 years, 146 SCD cases occurred. In a multivariable model adjusting for demographic, lifestyle, and metabolic factors, relative risk of SCD associated with each higher standard deviation (SD) of plasma FABP4 was 1.15 (95% CI: 0.95-1.38), P = 0.15. In a secondary analysis stratified by prevalent diabetes status, FABP4 was associated with higher risk of SCD in nondiabetic participants, (RR per SD higher FABP4: 1.33 (95% CI: 1.07-1.65), P = 0.009) but not in diabetic participants (RR per SD higher FABP4: 0.88 (95% CI: 0.62-1.27), P = 0.50), P for diabetes-FABP4 interaction 0.049. In summary, a single measure of plasma FABP4 obtained later in life was not associated with the risk of SCD in older adults overall. Confirmation of our post-hoc results in nondiabetic people in other studies is warranted.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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